Paul R. Roberts

TL;DR: The data indicate that long-term programming of postnatal growth and physiology can be induced irreversibly during the preimplantation period of development by maternal protein undernutrition, and proposes that the mildly hyperglycaemic and amino acid-depleted maternal environment generated by undernutrition may act as an early mechanism of programming and initiate conditions of 'metabolic stress', restricting early embryonic proliferation and the generation of appropriately sized stem-cell lineages.

TL;DR: The transcatheter pacemaker implanted in patients who had guideline-based indications for ventricular pacing met the prespecified safety and efficacy goals; it had a safety profile similar to that of a transvenous system while providing low and stable pacing thresholds.

TL;DR: Performance of the Micra transcatheter pacemaker in a real-world setting demonstrates a high rate (99.6%) of implant success and low rate of major complications through 30 days post implant, reinforcing the positive results seen in the investigational study.

TL;DR: Performance of the Micra transcatheter pacemaker in international clinical practice remains consistent with previously reported data, and major complications were infrequent and occurred 63% less often compared to transvenous systems.

TL;DR: It is hypothesized that the dialysis procedure itself may have important implications for SCD, and recognition that hemodialysis is associated with both ventricular arrhythmias and dynamic electrocardiographic changes, may show changes that are modifiable by alterations to dialysis prescription.