P
Paul Shapshak
Researcher at University of South Florida
Publications - 178
Citations - 4790
Paul Shapshak is an academic researcher from University of South Florida. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 38, co-authored 175 publications receiving 4624 citations. Previous affiliations of Paul Shapshak include Cornell University & University of California, Los Angeles.
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Journal ArticleDOI
The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis.
Alireza Minagar,Paul Shapshak,Robert K. Fujimura,Raymond L. Ownby,Melvin Heyes,Carl Eisdorfer +5 more
TL;DR: In these three diseases, cytokine/chemokine communications between M phi and astrocytes occur and are involved in the balance of protective and destructive actions by these cells.
Journal ArticleDOI
TNF- α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier
Milan Fiala,David Looney,Monique F. Stins,Dennis Way,Ling Zhang,Xiaohu Gan,Francesco Chiappelli,Erik S. Schweitzer,Paul Shapshak,Martin E. Weinand,Michael C. Graves,Marlys H. Witte,Kwang Sik Kim +12 more
TL;DR: Early after the infection, the blood-brain barrier protects the brain from HIV-1 asimmune mediators, such as TNF-α, open a paracellular route for the virus into the brain.
Journal ArticleDOI
A Bereavement Support Group Intervention Is Longitudinally Associated with Salutary Effects on the CD4 Cell Count and Number of Physician Visits
Karl Goodkin,Daniel J. Feaster,Deshratn Asthana,Nancy T. Blaney,Mahendra Kumar,Teri T. Baldewicz,Raymond S. Tuttle,Kevin Maher,Marianna K Baum,Paul Shapshak,Mary A Fletcher +10 more
TL;DR: The results indicate that behavioral interventions may have salutary immunological and clinical health effects following bereavement among HIV-1-infected individuals and that this bereavement support group intervention might have similarSalutary effects in the general population.
Journal ArticleDOI
Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality
Karl Goodkin,Francis L. Wilkie,Mauricio Concha,Charles H. Hinkin,Stephen Symes,Teri T. Baldewicz,Deshratn Asthana,Robert K. Fujimura,Diana Lee,M. H. van Zuilen,Imad Khamis,Paul Shapshak,Carl Eisdorfer +12 more
TL;DR: This review focuses on the neuropsychiatric and neurological conditions that are most likely to be affected by advancing age-HIV-1-associated cognitive-motor disorder, peripheral neuropathy, progressive multifocal leukoencephalopathy, primary CNS lymphoma, and risk for cerebrovascular accident.
Book ChapterDOI
Cocaine enhances monocyte migration across the blood-brain barrier. Cocaine's connection to AIDS dementia and vasculitis?
Milan Fiala,Xiaohu Gan,Laura Zhang,Steven D. House,Thomas F. Newton,Michael C. Graves,Paul Shapshak,Monique F. Stins,Kwang Sik Kim,Marlys H. Witte,Sulie L. Chang +10 more
TL;DR: In this article, molecular and cellular basis of cocaine's effects on immune and endothelial cells were analyzed. But, the effects of cocaine abuse on vascular pathology, including vasculitis, vasospasm and hemorrhage, were not investigated.