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Edna Teruko Kimura
Researcher at University of São Paulo
Publications - 121
Citations - 6680
Edna Teruko Kimura is an academic researcher from University of São Paulo. The author has contributed to research in topics: Thyroid cancer & Thyroid. The author has an hindex of 35, co-authored 113 publications receiving 6248 citations. Previous affiliations of Edna Teruko Kimura include Harvard University & University of Cincinnati.
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Journal Article
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Edna Teruko Kimura,Marina N. Nikiforova,Zhaowen Zhu,Jeffrey A. Knauf,Yuri E. Nikiforov,James A. Fagin +5 more
TL;DR: It is shown that a somatic mutation of BRAF, V599E, is the most common genetic change in PTCs, and represents a unique paradigm of human tumorigenesis through mutation of three signaling effectors lying in tandem.
Journal ArticleDOI
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
Marina N. Nikiforova,Edna Teruko Kimura,Manoj Gandhi,Paul W. Biddinger,Jeffrey A. Knauf,Fulvio Basolo,Zhaowen Zhu,Riccardo Giannini,Giuliana Salvatore,Alfredo Fusco,Massimo Santoro,James A. Fagin,Yuri E. Nikiforov +12 more
TL;DR: BRAF mutations are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas.
Journal ArticleDOI
Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Ana L. T. O. Nascimento,Albert I. Ko,Albert I. Ko,Elizabeth A. L. Martins,Claudia Barros Monteiro-Vitorello,Paulo L. Ho,David A. Haake,David A. Haake,Sergio Verjovski-Almeida,Rudy A. Hartskeerl,Marilis V. Marques,Mariana Cabral de Oliveira,Carlos Frederico Martins Menck,Luciana C. C. Leite,Helaine Carrer,Luiz Lehmann Coutinho,Wim Degrave,Odir Antônio Dellagostin,Hamza El-Dorry,Emer S. Ferro,Maria Inês Tiraboschi Ferro,Luiz Roberto Furlan,Marcia Gamberini,E. A. Giglioti,Aristóteles Góes-Neto,Gustavo H. Goldman,Maria Helena S. Goldman,Ricardo Harakava,Selma M. B. Jeronimo,Inácio L.M. Junqueira-de-Azevedo,Edna Teruko Kimura,Eiko E. Kuramae,Eliana Gertrudes de Macedo Lemos,Manoel Victor Franco Lemos,Celso Luis Marino,Luiz R. Nunes,R. C. de Oliveira,Gonçalo A.G. Pereira,Marcelo S. Reis,A. Schriefer,Walter José Siqueira,P. Sommer,Siu Mui Tsai,Andrew J. G. Simpson,Jesus Aparecido Ferro,Luis Eduardo Aranha Camargo,João Paulo Kitajima,João C. Setubal,M. A. Van Sluys +48 more
TL;DR: Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis.
Journal ArticleDOI
Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa
M. A. Van Sluys,M. C. de Oliveira,Claudia Barros Monteiro-Vitorello,Cristina Yumi Miyaki,Luiz Roberto Furlan,Luis Eduardo Aranha Camargo,A.C.R. da Silva,D. H. Moon,Marco Aurélio Takita,Eliana Gertrudes de Macedo Lemos,Marco Antonio Machado,Maria Inês Tiraboschi Ferro,F. R. da Silva,Maria Helena S. Goldman,Gustavo H. Goldman,Manoel Victor Franco Lemos,Hamza El-Dorry,Siu Mui Tsai,Helaine Carrer,Dirce Maria Carraro,R. C. de Oliveira,Luiz R. Nunes,Walter José Siqueira,Luiz Lehmann Coutinho,Edna Teruko Kimura,Emer S. Ferro,Ricardo Harakava,Eiko E. Kuramae,Celso Luis Marino,E. A. Giglioti,I. L. Abreu,Lucia Maria Carareto Alves,A. M. do Amaral,Gilson S. Baia,S. R. Blanco,Michael dos Santos Brito,Fabiana de Souza Cannavan,A. V. Celestino,A. F. Da Cunha,Roseli C. Fenille,Jesus Aparecido Ferro,Eduardo Fernandes Formighieri,Luciano Takeshi Kishi,S. G. Leoni,A. R. Oliveira,Vicente E. De Rosa,F. T. Sassaki,Janete Apparecida Desidério Sena,A. A. de Souza,Daniela Truffi,Fernando Tsukumo,Giane M. Yanai,Lilian Giotto Zaros,Edwin L. Civerolo,Andrew J. G. Simpson,Nalvo F. Almeida,João C. Setubal,João Paulo Kitajima +57 more
TL;DR: The genome sequence of X. fastidiosa (Temecula strain) is reported and it is concluded that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies.
Journal ArticleDOI
Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
Marcelo A. Christoffolete,Camila da Cruz Gouveia Linardi,Lucia A. de Jesus,Kátia N. Ebina,Suzy D. Carvalho,Miriam O. Ribeiro,Rogerio Rabelo,Cyntia Curcio,Luciane Martins,Edna Teruko Kimura,Antonio C. Bianco +10 more
TL;DR: The Dio2 gene encodes the type 2 deiodinase that activates thyroxine to 3,3',5-triiodothyronine, the disruption of which results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal, and it is shown that reduced adrenergic responsiveness does not limit cold-induced adaptive thermogenesis.