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Showing papers by "Paula Hoff published in 2018"

Journal Article•DOI•
Unraveling the role of hypoxia-inducible factor (HIF)-1α and HIF-2α in the adaption process of human microvascular endothelial cells (HMEC-1) to hypoxia: Redundant HIF-dependent regulation of macrophage migration inhibitory factor.

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M. Hahne1, Peggy Schumann1, Mathias Mursell1, C. Strehl1, Paula Hoff1, Frank Buttgereit1, Timo Gaber1 •
Charité1
01 Mar 2018-Microvascular Research
TL;DR: The macrophage migration inhibitory factor (MIF) is identified to be redundantly regulated by HIF-1 and Hif-2 and to be essential in the process of hypoxia-driven angiogenesis.

29 citations

Journal Article•DOI•
CTLA-4 Mediates Inhibitory Function of Mesenchymal Stem/Stromal Cells

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Timo Gaber1, Kerstin Schönbeck2, Kerstin Schönbeck1, Holger Hoff2, Cam Loan Tran2, Cam Loan Tran1, Cindy Strehl2, Cindy Strehl1, Annemarie Lang1, Annemarie Lang2, Sarah Ohrndorf1, Moritz Pfeiffenberger1, Moritz Pfeiffenberger2, Eric Röhner, Georg Matziolis, Gerd-R. Burmester1, Gerd-R. Burmester2, Frank Buttgereit1, Frank Buttgereit2, Paula Hoff •
Humboldt University of Berlin1, Leibniz Association2
07 Aug 2018-International Journal of Molecular Sciences
TL;DR: It is shown that depending on the environmental conditions, MSCs express different isoforms of CTLA-4 with the secreted isoform (sCTLA- 4) being the most abundant under hypoxic conditions and the immunosuppressive function of M SCs is mediated mainly by the secretion of CTla-4.
Abstract: Mesenchymal stem/stromal cells (MSCs) are stem cells of the connective tissue, possess a plastic phenotype, and are able to differentiate into various tissues. Besides their role in tissue regeneration, MSCs perform additional functions as a modulator or inhibitor of immune responses. Due to their pleiotropic function, MSCs have also gained therapeutic importance for the treatment of autoimmune diseases and for improving fracture healing and cartilage regeneration. However, the therapeutic/immunomodulatory mode of action of MSCs is largely unknown. Here, we describe that MSCs express the inhibitory receptor CTLA-4 (cytotoxic T lymphocyte antigen 4). We show that depending on the environmental conditions, MSCs express different isoforms of CTLA-4 with the secreted isoform (sCTLA-4) being the most abundant under hypoxic conditions. Furthermore, we demonstrate that the immunosuppressive function of MSCs is mediated mainly by the secretion of CTLA-4. These findings open new ways for treatment when tissue regeneration/fracture healing is difficult.

26 citations