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Paula L. Monteagudo
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 3
Citations - 74
Paula L. Monteagudo is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Innate immune system & Influenza A virus. The author has an hindex of 2, co-authored 3 publications receiving 46 citations. Previous affiliations of Paula L. Monteagudo include Autonomous University of Barcelona.
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Journal ArticleDOI
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.
Irene Ramos,Gregory R. Smith,Frederique Ruf-Zamojski,Carles Martínez-Romero,Miguel Fribourg,Edwin A. Carbajal,Boris M. Hartmann,Venugopalan D. Nair,Nada Marjanovic,Paula L. Monteagudo,Veronica A. DeJesus,Tinaye Mutetwa,Michel Zamojski,Gene S. Tan,Ciriyam Jayaprakash,Elena Zaslavsky,Randy A. Albrecht,Stuart C. Sealfon,Adolfo García-Sastre,Ana Fernandez-Sesma +19 more
TL;DR: It is found that the number of viruses infecting a cell influences the magnitude of virus antagonism of the host innate antiviral response, and Infections performed at high MOIs resulted in increased viral gene expression per cell and stronger antagonist effect than infections at low MOIs.
Journal ArticleDOI
Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
Paula L. Monteagudo,Raquel Muñoz-Moreno,Miguel Fribourg,Uma Potla,Ignacio Mena,Nada Marjanovic,Boris M. Hartmann,Stuart C. Sealfon,Adolfo García-Sastre,Irene Ramos,Ana Fernandez-Sesma +10 more
TL;DR: The results reveal an increased ability of NS1 from avian viruses to antagonize innate immune responses in human primary cells compared to the ability ofNS1 from human viruses, which could contribute to the severe disease induced by avian IAV in humans.
Journal ArticleDOI
Sirolimus enhances the protection achieved by a DNA vaccine against Leishmania infantum
Alba Martínez-Flórez,Clara Martori,Paula L. Monteagudo,Paula L. Monteagudo,Fernando Rodriguez,Jordi Alberola,Alhelí Rodríguez-Cortés +6 more
TL;DR: Analysis of immune markers in the spleen after challenge suggests that the trend to recover naïve levels of IFN-γ and IL-10, and the concurrent higher expression of NOS2, may be responsible for the protection induced by the vaccine co-administered with SIR.