Ignacio Mena

TL;DR: In this paper , the authors evaluated the ability of several B.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters.

TL;DR: SARS-CoV-2 is able to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of IFN-stimulated genes (ISGs).

TL;DR: It is established that the swine virus responsible for the 2009 A/H1N1 influenza pandemic virus evolved in central Mexico, highlighting how the 2009 pandemic arose from a region not considered a pandemic risk, owing to an expansion of IAV diversity in swine resulting from long-distance live swine trade.

TL;DR: It is demonstrated that Stat2-/- mice are highly susceptible to ZIKV infection, recapitulate virus spread to the central nervous system (CNS), gonads and other visceral organs, and display neurological symptoms, and this model is established a new murine model that supports ZikaV infection and demonstrates its utility in highlighting intrinsic differences in the inflammatory response induced by different ZikV strains leading to severity of disease.

TL;DR: The generation of a recombinant coxsackievirus B3 expressing the enhanced green fluorescent protein (eGFP) is described, which is used to mark and track infected cells in vitro and suggests that cell cycle status determines the distribution of CVB3 during acute infection and the persistence ofCVB3 in vivo may rely on infection of quiescent cells incapable of supporting viral replication.