G
Gregory R. Smith
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 25
Citations - 678
Gregory R. Smith is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Chromatin & Immune system. The author has an hindex of 9, co-authored 24 publications receiving 325 citations. Previous affiliations of Gregory R. Smith include Carnegie Mellon University.
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Journal ArticleDOI
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
James A. Sanford,Christopher D. Nogiec,Malene E. Lindholm,Joshua N. Adkins,David Amar,Surendra Dasari,Jonelle K. Drugan,Facundo M. Fernández,Shlomit Radom-Aizik,Simon Schenk,Michael Snyder,Russell P. Tracy,Patrick M. Vanderboom,Scott Trappe,Martin J. Walsh,Charles R. Evans,Yafeng Li,Lyl Tomlinson,D. Lee Alekel,Iddil Bekirov,Amanda T. Boyce,Josephine Boyington,Jerome L. Fleg,Lyndon Joseph,Maren R. Laughlin,Padma Maruvada,Stephanie A. Morris,Joan McGowan,Concepcion R. Nierras,Vinay Pai,Charlotte A. Peterson,Ed Ramos,Mary Roary,John P. Williams,Ashley Xia,Elaine Cornell,Jessica Rooney,Michael Miller,Walter T. Ambrosius,Scott Rushing,Cynthia L. Stowe,W. Jack Rejeski,Barbara J. Nicklas,Marco Pahor,Ching-ju Lu,Todd A. Trappe,Toby Chambers,Ulrika Raue,Bridget Lester,Bryan C. Bergman,David H. Bessesen,Catherine M. Jankowski,Wendy M. Kohrt,Edward L. Melanson,Kerrie L. Moreau,Irene E. Schauer,Robert S. Schwartz,William E. Kraus,Cris A. Slentz,Kim M. Huffman,Johanna L. Johnson,Leslie H. Willis,L S. Kelly,Joseph A. Houmard,Gabriel S. Dubis,Nick Broskey,Bret H. Goodpaster,Lauren M. Sparks,Paul M. Coen,Dan M. Cooper,Fadia Haddad,Tuomo Rankinen,Eric Ravussin,Neil M. Johannsen,Melissa Harris,John M. Jakicic,Anne B. Newman,Daniel Forman,Erin E. Kershaw,Renee J. Rogers,Bradley C. Nindl,Lindsay C. Page,Maja Stefanovic-Racic,Susan Barr,Blake B. Rasmussen,Tatiana Moro,Doug Paddon-Jones,Elena Volpi,Heidi Spratt,Nicolas Musi,Sara E. Espinoza,Darpan I. Patel,Monica C. Serra,Jonathan Gelfond,Aisling Burns,Marcas M. Bamman,Thomas W. Buford,Gary Cutter,Sue C. Bodine,Karyn A. Esser,Rodger P. Farrar,Laurie J. Goodyear,Michael F. Hirshman,Brent G. Albertson,Wei-Jun Qian,Paul D. Piehowski,Marina A. Gritsenko,Matthew E. Monore,Vladislav A. Petyuk,Jason E. McDermott,Joshua N. Hansen,Chelsea Hutchison,Samuel G. Moore,David A. Gaul,Clary B. Clish,Julian Avila-Pacheco,Courtney Dennis,Manolis Kellis,Steve Carr,Pierre M. Jean-Beltran,Hasmik Keshishian,D. R. Mani,Karl R. Clauser,Karsten Krug,Charlie Mundorff,Cadence Pearce,Anna A. Ivanova,Eric A. Ortlund,Kristal M. Maner-Smith,Karan Uppal,Tiantian Zhang,Stuart C. Sealfon,Elena Zaslavsky,Venugopalan D. Nair,SiDe Li,Nimisha Jain,Yongchao Ge,Yifei Sun,German Nudelman,Frederique Ruf-Zamojski,Gregory R. Smith,Nhanna Pincas,Aliza B. Rubenstein,Mary Anne S. Amper,Nitish Seenarine,Tuuli Lappalainen,Ian R. Lanza,K. Sreekumaran Nair,Katherine Klaus,Stephen B. Montgomery,Kevin S. Smith,Bingqing Zhao,Chia-Jiu Hung,Navid Zebarjadi,Brunilda Balliu,Laure Fresard,Charles F. Burant,Jun Li,Maureen Kachman,Tanu Soni,Alexander B. Raskind,Robert E. Gerszten,Jeremy M. Robbins,Olga Ilkayeva,Michael J. Muehlbauer,Christopher B. Newgard,Euan A. Ashley,Matthew T. Wheeler,David Jimenez-Morales,Archana Raja,Karen P. Dalton,Jimmy Zhen,Young Suk Kim,Jeffrey W. Christle,Shruti Marwaha,Elizabeth T Chin,Steven G. Hershman,Trevor Hastie,Robert Tibshirani,Manuel A. Rivas +179 more
TL;DR: The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will provide a public database that is expected to enhance the understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
Journal ArticleDOI
Single-cell transcriptional profiles in human skeletal muscle.
Aliza B. Rubenstein,Gregory R. Smith,Ulrika Raue,Gwenaelle Begue,Kiril Minchev,Frederique Ruf-Zamojski,Venugopalan D. Nair,Xingyu Wang,Lan Zhou,Elena Zaslavsky,Todd A. Trappe,Scott Trappe,Stuart C. Sealfon +12 more
TL;DR: This work analyzed public transcriptome data from an exercise training study and revealed significant changes in specific mononuclear cell-type proportions related to age, sex, acute exercise and training and will further the understanding of the diverse effects of exercise and the pathophysiology of muscle disease.
Journal ArticleDOI
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.
Irene Ramos,Gregory R. Smith,Frederique Ruf-Zamojski,Carles Martínez-Romero,Miguel Fribourg,Edwin A. Carbajal,Boris M. Hartmann,Venugopalan D. Nair,Nada Marjanovic,Paula L. Monteagudo,Veronica A. DeJesus,Tinaye Mutetwa,Michel Zamojski,Gene S. Tan,Ciriyam Jayaprakash,Elena Zaslavsky,Randy A. Albrecht,Stuart C. Sealfon,Adolfo García-Sastre,Ana Fernandez-Sesma +19 more
TL;DR: It is found that the number of viruses infecting a cell influences the magnitude of virus antagonism of the host innate antiviral response, and Infections performed at high MOIs resulted in increased viral gene expression per cell and stronger antagonist effect than infections at low MOIs.
Journal ArticleDOI
Drug response consistency in CCLE and CGP
Mehdi Bouhaddou,Matthew S. DiStefano,Eric A. Riesel,Emilce Carrasco,Hadassa Y. Holzapfel,DeAnalisa C. Jones,Gregory R. Smith,Alan D Stern,Sulaiman Somani,T. Victoria Thompson,Marc R. Birtwistle +10 more
TL;DR: Two metrics of drug responsiveness (slope and area under the curve) that are derived from the original CCLE and CGP data are examined and find reasonable and statistically significant consistency, reviving confidence that the CCLEand CGP drug dose–response data are of sufficient quality for meaningful analyses.
Journal ArticleDOI
Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages.
Xingyu Wang,Adwait Amod Sathe,Gregory R. Smith,Frederique Ruf-Zamojski,Venugopalan D. Nair,Kory J. Lavine,Chao Xing,Stuart C. Sealfon,Lan Zhou +8 more
TL;DR: It is demonstrated that skeletal muscle-resident macrophages originate from both embryonic hematopoietic progenitors located within the yolk sac and fetal liver as well as definitive hematopolietic stem cells Located within the bone marrow of adult mice.