Paula Restrepo

TL;DR: Findings confirm findings from previous studies suggesting human exposure to OPFRs, and demonstrate, for the first time, widespread exposure to several OPFRS among a representative sample of the U.S. general population 6years of age and older.

TL;DR: An analytical method for measuring 12 biomarkers of several of these pesticides in urine that can be used to measure all the target analytes in one injection with similar repeatability and detection limits of previous methods which required more than one injection is developed.

TL;DR: A method to quantify nine compounds in 0.4 mL urine that relies on an enzymatic hydrolysis of urinary conjugates of the target analytes, automated off-line solid phase extraction, reversed phase high performance liquid chromatography separation, and isotope dilution-electrospray ionization tandem mass spectrometry detection is developed.

TL;DR: The data indicate that the most vulnerable segments of the population—children and older adults—have higher exposures to OP pesticides than other population segments, however, according to DAP urinary metabolite data, exposures toOP pesticides have declined during the last six years at both the median and 95th percentile levels.

TL;DR: Using this method, concentrations of the target chemicals in urine samples from the general population were measured and the average coefficient of variation was below 15% for most of the analytes.