P
Paulina Piesik
Researcher at University of British Columbia
Publications - 4
Citations - 226
Paulina Piesik is an academic researcher from University of British Columbia. The author has contributed to research in topics: Signal transducing adaptor protein & Autophagy. The author has an hindex of 3, co-authored 4 publications receiving 187 citations.
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Journal ArticleDOI
Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling.
Junyan Shi,Jerry Wong,Paulina Piesik,Gabriel Fung,Jingchun Zhang,Julienne Jagdeo,Xiaotao Li,Eric Jan,Honglin Luo +8 more
TL;DR: The results suggest a novel model by which cleavage of SQSTM1 as a result of CVB3 infection impairs the function of SQ STM1 in selective autophagy and host defense signaling.
Journal ArticleDOI
Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during CVB3 infection.
Gabriel Fung,Chen Seng Ng,Jingchun Zhang,Junyan Shi,Jerry Wong,Paulina Piesik,Lillian Han,Fanny Chu,Julienne Jagdeo,Eric Jan,Takashi Fujita,Honglin Luo +11 more
TL;DR: The studies demonstrated that SGs were formed early during CVB3 infection; however, G3BP1-positiveSGs were actively disassembled at 5 hrs post-infection, while poly(A)-positive RNA granules persisted, and evidence that the C-terminal cleavage product of G3 BP1 inhibited SG formation and promotedCVB3 replication was provided.
Journal ArticleDOI
Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection
TL;DR: A novel mechanism through which coxsackievirus infection induces increased accumulation of ubiquitin conjugates and subsequent viral damage is suggested.