E
Eric Jan
Researcher at University of British Columbia
Publications - 78
Citations - 4359
Eric Jan is an academic researcher from University of British Columbia. The author has contributed to research in topics: Translation (biology) & Internal ribosome entry site. The author has an hindex of 31, co-authored 68 publications receiving 3801 citations. Previous affiliations of Eric Jan include Stanford University & Northwestern University.
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The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Gabriel Leprivier,Marc Remke,Marc Remke,Barak Rotblat,Adrian M. Dubuc,Abigail Rachele F. Mateo,Marcel Kool,Sameer Agnihotri,Amal El-Naggar,Bin Yu,Syam Prakash Somasekharan,Brandon Faubert,Gaëlle Bridon,Cristina E. Tognon,Joan Mathers,Ryan Thomas,Amy Li,Adi Barokas,Brian Kwok,Mary Bowden,Stephanie Smith,Xiaochong Wu,Andrey Korshunov,Thomas Hielscher,Paul A. Northcott,Jason D. Galpin,Christopher A. Ahern,Ye Wang,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Russell G. Jones,Michael Pollak,Olivier Delattre,Martin E. Gleave,Eric Jan,Stefan M. Pfister,Stefan M. Pfister,Christopher G. Proud,W. Brent Derry,Michael D. Taylor,Poul H. Sorensen +41 more
TL;DR: It is reported that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Journal ArticleDOI
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes: The IRES Functions as an RNA-Based Translation Factor
Christian M. T. Spahn,Eric Jan,Anke M. Mulder,Anke M. Mulder,Anke M. Mulder,Robert A. Grassucci,Robert A. Grassucci,Peter Sarnow,Joachim Frank,Joachim Frank,Joachim Frank +10 more
TL;DR: Cryo-EM structures of the CrPV IRES bound to the human ribosomal 40S subunit and to the 80S ribosome show that CrPVs-like IRES elements seem to act as RNA-based translation factors.
Journal ArticleDOI
Factorless Ribosome Assembly on the Internal Ribosome Entry Site of Cricket Paralysis Virus
Eric Jan,Peter Sarnow +1 more
TL;DR: Results suggest that the IGR IRES has distinct pseudoknot-like structures that make multiple contacts with the ribosome resulting in initiation factor-independent recruitment and correct positioning of the ribOSome on the mRNA.
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Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism
Barry P. Young,John J.H. Shin,Rick Orij,Jesse T. Chao,Shu Chen Li,Xue Li Guan,Xue Li Guan,Anthony Khong,Eric Jan,Markus R. Wenk,Markus R. Wenk,Markus R. Wenk,William A. Prinz,Gertien J. Smits,Christopher J. R. Loewen +14 more
TL;DR: In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes, which enabled coupling of membrane biogenesis to nutrient availability.
Journal ArticleDOI
The STAR protein, GLD‐1, is a translational regulator of sexual identity in Caenorhabditis elegans
TL;DR: Using the yeast three‐hybrid screen and RNA gel shift analysis, it is found that the protein GLD‐1, a germline‐specific protein and a member of the STAR family of RNA‐binding proteins, specifically binds to the 3′‐untranslated region called TGEs.