T
Takashi Fujita
Researcher at Kyoto University
Publications - 271
Citations - 40823
Takashi Fujita is an academic researcher from Kyoto University. The author has contributed to research in topics: Interferon & RNA. The author has an hindex of 79, co-authored 250 publications receiving 38018 citations. Previous affiliations of Takashi Fujita include Osaka University & University Hospital Bonn.
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Journal ArticleDOI
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama,Mika Kikuchi,Takashi Natsukawa,Noriaki Shinobu,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Shizuo Akira,Takashi Fujita +8 more
TL;DR: In this article, the authors identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling.
Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
Journal ArticleDOI
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Makoto Miyagishi,Kazunari Taira,Kazunari Taira,Eileen Foy,Yueh Ming Loo,Michael Gale,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita +14 more
TL;DR: The results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
Journal ArticleDOI
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
Hiroki Kato,Osamu Takeuchi,Eriko Mikamo-Satoh,Eriko Mikamo-Satoh,Reiko Hirai,Tomoji Kawai,Kazufumi Matsushita,Akane Hiiragi,Terence S. Dermody,Takashi Fujita,Shizuo Akira +10 more
TL;DR: It is shown that the length of dsRNA is important for differential recognition by RIG-I and MDA5, and the Mda5 ligand, polyinosinic-polycytidylic acid, was converted to a Rig-I ligand after shortening of the ds RNA length.
Journal ArticleDOI
A new protein containing an SH2 domain that inhibits JAK kinases
Takaho A. Endo,Masaaki Masuhara,Masahiro Yokouchi,Ritsu Suzuki,Hiroshi Sakamoto,Kaoru Mitsui,Akira Matsumoto,Shyu Tanimura,Motoaki Ohtsubo,Hiroyuki Misawa,Tadaaki Miyazaki,Nogueira Leonor,Tadatsugu Taniguchi,Takashi Fujita,Yuzuru Kanakura,S. Komiya,Akihiko Yoshimura +16 more
TL;DR: A new SH2-domain-containing protein is isolated, JAB, which is a JAK-binding protein that interacts with the Jak2 tyrosine-kinase JH1 domain, and JAB and CIS appear to function as negative regulators in the JAK signalling pathway.