Paulo Costa

TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).

TL;DR: In this review, it is intended to discuss the recent advances related on the area of solid dispersions.

TL;DR: This paper addresses an alternative method to the evaluation of similarity factor f(2) as a criterion for assessment of similarity between two in-vitro dissolution profiles as proposed in the SUPAC-IR Guidance (1995).

TL;DR: The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery and results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness.

TL;DR: The results indicate that this technology can be successfully applied to modulate the bioavailability of drugs for percutaneous administration, which could be particularly advantageous in the design of delivery systems that have, simultaneously, the ability to absorb exudates and to adhere to irregular skin surfaces.