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Paulo W. Pires
Researcher at University of Arizona
Publications - 36
Citations - 1544
Paulo W. Pires is an academic researcher from University of Arizona. The author has contributed to research in topics: Cerebral arteries & Vasodilation. The author has an hindex of 17, co-authored 33 publications receiving 1169 citations. Previous affiliations of Paulo W. Pires include Michigan State University & State University of Campinas.
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Journal ArticleDOI
The effects of hypertension on the cerebral circulation
TL;DR: This review will focus on the historical discoveries, novel developments, and knowledge gaps in 1) hypertensive cerebral artery remodeling, 2) vascular function with emphasis on myogenic reactivity and endothelium-dependent dilation, and 3) blood-brain barrier function.
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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
Amy McCurley,Paulo W. Pires,Shawn B. Bender,Mark Aronovitz,Michelle J Zhao,Daniel Metzger,Pierre Chambon,Michael A. Hill,Anne M. Dorrance,Michael E Mendelsohn,Michael E Mendelsohn,Iris Z. Jaffe +11 more
TL;DR: It is shown that mice with SMC-specific deficiency of the MR have decreased blood pressure as they age without defects in renal sodium handling or vascular structure, which supports the emerging hypothesis that vascular tone contributes directly to systemic blood pressure.
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Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation
Michelle N. Sullivan,Albert L. Gonzales,Paulo W. Pires,Allison Bruhl,M. Dennis Leo,Wencheng Li,Agathe Oulidi,Frederick A. Boop,Yumei Feng,Jonathan H. Jaggar,Donald G. Welsh,Scott Earley +11 more
TL;DR: The data suggest that in the cerebral circulation, lipid peroxidation metabolites generated by ROS activate Ca2+ influx through TRPA1 channels in the endothelium of cerebral arteries to cause dilation.
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Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats
Paulo W. Pires,Curt Thomas Rogers,Jonathon L. McClain,Hannah Garver,Gregory D. Fink,Anne M. Dorrance +5 more
TL;DR: It is suggested that MMPs are involved in hypertensive vascular remodeling in both the peripheral and cerebral vasculature and that DOX reduced brain damage after cerebral ischemia.
Journal ArticleDOI
The effects of obesity on the cerebral vasculature.
TL;DR: The effects of obesity on cerebral artery function and structure are discussed, including the endothelium and nitric oxide (NO) dependent dilation and the evidence that links these changes in vascular structure and function to cognitive decline and dementia.