Pavel Morozov

TL;DR: A critical overview of miRNA dysregulation in cancer is provided, first discussing the methods currently available for studying the role of miRNAs in cancer and then reviewing miRNA genomic organization, biogenesis and mechanism of target recognition.

TL;DR: Bias in representation of miRNAs relative to their input concentration was assessed, and the influence of 5'-terminal 5-nt barcode extensions for a set of 20 barcoded 3' adapters observed similar biases in miRNA read distribution, thereby enabling cost-saving multiplex analysis for large-scale miRNA profiling.

TL;DR: In this paper, miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing seed-sequence-dependent miRNA-target regulation, showing that normal breast samples were separated from most non-invasive ductal carcinoma in situ and invasive carcinomas by increased miR-21 (the most abundant miRNA in carcinomas) and multiple decreased miRNA families, with most miRNA changes apparent already in the noninvasive carcinomas.

TL;DR: This study provides a blueprint to further the understanding of the roles of these cells in the placenta and decidua for maintenance of early gestation as well as pathogenesis in pregnancy-related disorders.

TL;DR: These findings provide the underpinning for miRNA-based therapies and emphasize the usefulness of circulating miRNAs as biomarkers for heart injury performing similar to established diagnostic protein biomarkers.