R
Ruiping Ji
Researcher at Columbia University Medical Center
Publications - 31
Citations - 1173
Ruiping Ji is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Heart failure & Ventricular assist device. The author has an hindex of 14, co-authored 28 publications receiving 856 citations. Previous affiliations of Ruiping Ji include Columbia University.
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Journal ArticleDOI
Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure
Aalap Chokshi,Konstantinos Drosatos,Faisal H. Cheema,Ruiping Ji,Tuba Khawaja,Shuiqing Yu,Tomoko Kato,Raffay S. Khan,Hiroo Takayama,Ralph Knöll,Hendrik Milting,Hendrik Milting,Christine Chung,Ulrich P. Jorde,Yoshifumi Naka,Donna Mancini,Ira J. Goldberg,P. Christian Schulze +17 more
TL;DR: Mechanical unloading after left ventricular assist device implantation corrects systemic and local metabolic derangements in advanced heart failure, leading to reduced myocardial levels of toxic lipid intermediates and improved cardiac insulin signaling.
Journal ArticleDOI
Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers
Kemal M. Akat,D’Vesharronne Moore-McGriff,Pavel Morozov,Miguel Brown,Tasos Gogakos,Joel Correa da Rosa,Aleksandra Mihailovic,Markus Sauer,Ruiping Ji,Aarthi Ramarathnam,Hana Totary-Jain,Zev Williams,Thomas Tuschl,P. Christian Schulze +13 more
TL;DR: These findings provide the underpinning for miRNA-based therapies and emphasize the usefulness of circulating miRNAs as biomarkers for heart injury performing similar to established diagnostic protein biomarkers.
Journal ArticleDOI
Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.
Brittany A. Law,Xianghai Liao,Kelsey Moore,Abigail Southard,Patrick Roddy,Ruiping Ji,Zdzislaw M. Szulc,Ala Bielawska,P. Christian Schulze,P. Christian Schulze,L. Ashley Cowart +10 more
TL;DR: The results support a model by which CerS2 and VLC ceramides have a distinct role in lipotoxicity, leading to mitochondrial damage, which results in subsequent adaptive mitophagy, which causes cell death in cardiomyocytes.
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MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation
Xiaokan Zhang,Ruiping Ji,Xianghai Liao,Estibaliz Castillero,Peter J. Kennel,Danielle L. Brunjes,Marcus Franz,Sven Möbius-Winkler,Konstantinos Drosatos,Isaac George,Emily I. Chen,Paolo C. Colombo,P. Christian Schulze,P. Christian Schulze +13 more
TL;DR: It is suggested that increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of PDH and ATP synthase that are essential for cardiac energy metabolism.
Journal ArticleDOI
Increased de novo ceramide synthesis and accumulation in failing myocardium
Ruiping Ji,Hirokazu Akashi,Konstantinos Drosatos,Xianghai Liao,Hongfeng Jiang,Peter J. Kennel,Danielle L. Brunjes,Estibaliz Castillero,Xiaokan Zhang,Lily Y. Deng,Shunichi Homma,I. George,Hiroo Takayama,Yoshifumi Naka,Ira J. Goldberg,Ira J. Goldberg,P. Christian Schulze,P. Christian Schulze +17 more
TL;DR: Cardiac ceramides accumulate in the failing myocardium, and increased levels are detectable in circulation, and inhibition of de novo ceramide synthesis reduces cardiac remodeling.