P
Pawan Upadhyay
Researcher at Homi Bhabha National Institute
Publications - 20
Citations - 506
Pawan Upadhyay is an academic researcher from Homi Bhabha National Institute. The author has contributed to research in topics: Mutation & Medicine. The author has an hindex of 10, co-authored 17 publications receiving 388 citations. Previous affiliations of Pawan Upadhyay include Tata Memorial Hospital & Cancer Research Institute.
Papers
More filters
Journal ArticleDOI
Frequency of EGFR Mutations in 907 Lung Adenocarcioma Patients of Indian Ethnicity
Anuradha Chougule,Kumar Prabhash,Vanita Noronha,Amit Joshi,Abhishek Thavamani,Pratik Chandrani,Pawan Upadhyay,Sagarika Utture,Saral Desai,Nirmala A. Jambhekar,Amit Dutt +10 more
TL;DR: The intermediate frequency of EGFR mutation among Indian population compared to Caucasians and East Asians is reminiscent of an ancestral admixture of genetic influence from Middle Easterners, Central Asians, and Europeans on modern- Indian population that may confer differential susceptibility to somatic mutations in EGFR.
Journal ArticleDOI
MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes
TL;DR: The first report of MYOD1 (L122R) mutation in the largest cohort of 49 rhabdomyosarcomas reported so far, that are associated with a relatively aggressive clinical course is presented.
Journal ArticleDOI
Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes
Indraneel Mittra,Naveen Kumar Khare,Gorantla V. Raghuram,Rohan Chaubal,Fatema Khambatti,Deepika Gupta,Ashwini Gaikwad,Preeti Prasannan,Akshita Singh,Aishwarya Iyer,Ankita Singh,Pawan Upadhyay,Naveen K Nair,Pradyumna Kumar Mishra,Amit Dutt +14 more
TL;DR: Results that circulating DNAfs and Cfs are physiological, continuously arising, endogenous DNA damaging agents with implications to ageing and a multitude of human pathologies including initiation of cancer are reported.
Journal ArticleDOI
NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome
Pratik Chandrani,Kulkarni,Prajish Iyer,Pawan Upadhyay,Chaubal R,Pragnya Das,Rita Mulherkar,R. K. Singh,Amit Dutt +8 more
TL;DR: HPVDetector is a simple yet precise and robust tool for detecting HPV from tumour samples using variety of next-generation sequencing platforms including whole genome, whole exome and transcriptome.
Journal ArticleDOI
Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer
Pawan Upadhyay,Sudhir Nair,Ekjot Kaur,Jyotirmoi Aich,Prachi Dani,Vidyalakshmi Sethunath,Nilesh Gardi,Pratik Chandrani,Mukul Godbole,Kavita Sonawane,Ratnam Prasad,Sadhana Kannan,Beamon Agarwal,Shubhada Kane,Sudeep Gupta,Shilpee Dutt,Amit Dutt +16 more
TL;DR: A novel clinical and functional significance of NOTCH1 alterations in early stage tongue squamous cell carcinoma is presented and it is anticipated that these results could form the basis for therapeutic targeting of Notch1 in tongue cancer.