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Amit Dutt
Researcher at Homi Bhabha National Institute
Publications - 97
Citations - 8258
Amit Dutt is an academic researcher from Homi Bhabha National Institute. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 27, co-authored 84 publications receiving 7430 citations. Previous affiliations of Amit Dutt include University of Zurich & Brigham and Women's Hospital.
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Journal ArticleDOI
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding,Gad Getz,David A. Wheeler,Elaine R. Mardis,Michael D. McLellan,Kristian Cibulskis,Carrie Sougnez,Heidi Greulich,Heidi Greulich,Donna M. Muzny,Margaret Morgan,Lucinda Fulton,Robert S. Fulton,Qunyuan Zhang,Michael C. Wendl,Michael S. Lawrence,David E. Larson,Ken Chen,David J. Dooling,Aniko Sabo,Alicia Hawes,Hua Shen,Shalini N. Jhangiani,Lora Lewis,Otis Hall,Yiming Zhu,Tittu Mathew,Yanru Ren,Jiqiang Yao,Steven E. Scherer,Kerstin Clerc,Ginger A. Metcalf,Brian Ng,Aleksandar Milosavljevic,Manuel L. Gonzalez-Garay,John R. Osborne,Rick Meyer,Xiaoqi Shi,Yuzhu Tang,Daniel C. Koboldt,Ling Lin,Rachel Abbott,Tracie L. Miner,Craig Pohl,Ginger A. Fewell,Carrie A. Haipek,Heather Schmidt,Brian H. Dunford-Shore,Aldi T. Kraja,Seth D. Crosby,Christopher S. Sawyer,Tammi L. Vickery,Sacha N. Sander,Jody S. Robinson,Wendy Winckler,Wendy Winckler,Jennifer Baldwin,Lucian R. Chirieac,Amit Dutt,Amit Dutt,Timothy Fennell,Megan Hanna,Megan Hanna,Bruce E. Johnson,Robert C. Onofrio,Roman K. Thomas,Giovanni Tonon,Barbara A. Weir,Barbara A. Weir,Xiaojun Zhao,Xiaojun Zhao,Liuda Ziaugra,Michael C. Zody,Thomas J. Giordano,Mark B. Orringer,Jack A. Roth,Margaret R. Spitz,Ignacio I. Wistuba,Bradley A. Ozenberger,Peter J. Good,Andrew C. Chang,David G. Beer,Mark A. Watson,Marc Ladanyi,Stephen R. Broderick,Akihiko Yoshizawa,William D. Travis,William Pao,Michael A. Province,George M. Weinstock,Harold E. Varmus,Stacey Gabriel,Eric S. Lander,Richard A. Gibbs,Matthew Meyerson,Matthew Meyerson,Richard K. Wilson +96 more
TL;DR: Somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B are found.
Journal ArticleDOI
High-throughput oncogene mutation profiling in human cancer
Roman K. Thomas,Alissa C. Baker,Ralph M. Debiasi,Ralph M. Debiasi,Wendy Winckler,Wendy Winckler,Thomas LaFramboise,Thomas LaFramboise,William M. Lin,William M. Lin,Meng Wang,Meng Wang,Whei Feng,Whei Feng,Thomas Zander,Laura E. MacConnaill,Laura E. MacConnaill,Jeffrey C. Lee,Jeffrey C. Lee,Rick Nicoletti,Rick Nicoletti,Charlie Hatton,Charlie Hatton,Mary Goyette,Luc Girard,Kuntal Majmudar,Liuda Ziaugra,Kwok-Kin Wong,Stacey Gabriel,Rameen Beroukhim,Rameen Beroukhim,Michael Peyton,Jordi Barretina,Jordi Barretina,Amit Dutt,Amit Dutt,Caroline Emery,Heidi Greulich,Heidi Greulich,Kinjal Shah,Kinjal Shah,Hidefumi Sasaki,Adi F. Gazdar,John D. Minna,Scott A. Armstrong,Ingo K. Mellinghoff,F. Stephen Hodi,Glenn Dranoff,Paul S. Mischel,Timothy F. Cloughesy,Stan F. Nelson,Linda M. Liau,Kirsten D. Mertz,Kirsten D. Mertz,Mark A. Rubin,Holger Moch,Massimo Loda,William J. Catalona,Jonathan A. Fletcher,Sabina Signoretti,Frederic J. Kaye,Kenneth C. Anderson,George D. Demetri,Reinhard Dummer,Stephan N. Wagner,Meenhard Herlyn,William R. Sellers,William R. Sellers,Matthew Meyerson,Matthew Meyerson,Levi A. Garraway,Levi A. Garraway +71 more
TL;DR: High-throughput genotyping is adapted to query 238 known oncogene mutations across 1,000 human tumor samples and established robust mutation distributions spanning 17 cancer types, offering a new dimension in tumor genetics, where mutations involving multiple cancer genes may be interrogated simultaneously and in 'real time'.
Journal ArticleDOI
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Adam J. Bass,Adam J. Bass,Hideo Watanabe,Hideo Watanabe,Craig H. Mermel,Craig H. Mermel,Soyoung Yu,Sven Perner,Sven Perner,Roeland Verhaak,Roeland Verhaak,So Young Kim,Leslie Wardwell,Pablo Tamayo,Irit Gat-Viks,Alex H. Ramos,Alex H. Ramos,Michele S. Woo,Michele S. Woo,Barbara A. Weir,Barbara A. Weir,Gad Getz,Rameen Beroukhim,Rameen Beroukhim,Michael O'Kelly,Amit Dutt,Amit Dutt,Orit Rozenblatt-Rosen,Piotr Dziunycz,Justin Komisarof,Lucian R. Chirieac,Christopher J. LaFargue,Veit Scheble,Theresia Wilbertz,Changqing Ma,Shilpa Rao,Hiroshi Nakagawa,Douglas B. Stairs,Lin Lin,Thomas J. Giordano,Patrick L. Wagner,John D. Minna,Adi F. Gazdar,Chang-Qi Zhu,Marcia S. Brose,Ivan Cecconello,Ulysses Ribeiro,Suely Kazue Nagahashi Marie,Olav Dahl,Ramesh A. Shivdasani,Ming-Sound Tsao,Mark A. Rubin,Kwok K. Wong,Aviv Regev,William C. Hahn,William C. Hahn,David G. Beer,Anil K. Rustgi,Matthew Meyerson,Matthew Meyerson +59 more
TL;DR: A peak of genomic amplification on chromosome 3q26.33 found in squamous cell carcinomas of the lung and esophagus contains the transcription factor gene SOX2, which is necessary for normal esophageal squamous development, promotes differentiation and proliferation of basal tracheal cells and cooperates in induction of pluripotent stem cells.
Journal ArticleDOI
Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Peter S. Hammerman,Martin L. Sos,Alex H. Ramos,Chunxiao Xu,Amit Dutt,Wenjun Zhou,Lear E. Brace,Brittany Woods,Wenchu Lin,Jianming Zhang,Xianming Deng,Sang Min Lim,Stefanie Heynck,Martin Peifer,Jeffrey R. Simard,Michael S. Lawrence,Robert C. Onofrio,Helga B. Salvesen,Danila Seidel,Thomas Zander,Johannes M. Heuckmann,Alex Soltermann,Holger Moch,Mirjam Koker,Frauke Leenders,Frauke Leenders,Franziska Gabler,Silvia Querings,Sascha Ansén,Elisabeth Brambilla,Christian Brambilla,Philippe Lorimier,Odd Terje Brustugun,Åslaug Helland,Iver Petersen,Joachim H. Clement,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erich Stoelben,Juergen Wolf,David G. Beer,Ming-Sound Tsao,Megan Hanna,Megan Hanna,Charlie Hatton,Charlie Hatton,Michael J. Eck,Pasi A. Jänne,Bruce E. Johnson,Wendy Winckler,Heidi Greulich,Heidi Greulich,Adam J. Bass,Jeonghee Cho,Daniel Rauh,Nathanael S. Gray,Kwok-Kin Wong,Eric B. Haura,Roman K. Thomas,Matthew Meyerson,Matthew Meyerson +61 more
TL;DR: Findings suggest that gain-of-function mutations in DDR2 are important oncogenic events and are amenable to therapy with dasatinib, and provide a rationale for designing clinical trials with the FDA-approved drug d asatinib in patients with lung SCCs.
Journal ArticleDOI
Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
Amit Dutt,Alex H. Ramos,Alex H. Ramos,Peter S. Hammerman,Craig H. Mermel,Craig H. Mermel,Jeonghee Cho,Tanaz Sharifnia,Tanaz Sharifnia,Ajit Chande,Kumiko Elisa Tanaka,Kumiko Elisa Tanaka,Nicolas Stransky,Heidi Greulich,Heidi Greulich,Heidi Greulich,Nathanael S. Gray,Matthew Meyerson +17 more
TL;DR: It is demonstrated that a non-small cell lung carcinoma cell line harboring focal amplification of FGFR1 is dependent onFGFR1 activity for cell growth, as treatment of this cell line either with FG FR1-specific shRNAs or with FGFR small molecule enzymatic inhibitors leads to cell growth inhibition.