Pedro H.D.M. Prazeres

TL;DR: This study shows that pericytes from within the same tissue may be heterogeneous in their origin, and remarkably, a subpopulation of embryonic dermal pericycletes derives from the hematopoietic lineage, an unexpected source.

TL;DR: Strikingly, pericytes support glioblastoma growth in vitro and in vivo and develop an immunosuppressive phenotype, reducing T‐cell activation through the induction of an anti‐inflammatory response.

TL;DR: It is revealed that lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia and that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs.

TL;DR: It is demonstrated using state-of-the-art techniques, including deletion of several genes from endothelial cells, that PDGFB/PDGFRβ signaling is indispensable in the formation and maturation of bloodretinal-barrier at the postnatal stage through active recruitment of pericytes onto the growing retinal vessels.

TL;DR: It is suggested that sensory innervations counteract melanoma progression, and provides a novel target in the tumour microenvironment for therapeutic benefit in cancer patients.