P
Pedro Velasquez-Mieyer
Researcher at University of Tennessee Health Science Center
Publications - 25
Citations - 845
Pedro Velasquez-Mieyer is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Insulin & Overweight. The author has an hindex of 14, co-authored 25 publications receiving 788 citations. Previous affiliations of Pedro Velasquez-Mieyer include University of Tennessee.
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Journal ArticleDOI
Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist.
Robert H. Lustig,Susan R. Rose,George A. Burghen,Pedro Velasquez-Mieyer,Dean C. Broome,Karen Smith,Hao Li,Melissa M. Hudson,Richard L. Heideman,Larry E. Kun +9 more
TL;DR: The results suggest that normalization of insulin secretion may be an effective therapeutic strategy in this syndrome and that pre-study biochemical glucose tolerance improved in several patients while they were receiving octreotide.
Journal ArticleDOI
Obesity, leptin resistance, and the effects of insulin reduction.
TL;DR: The results suggest that the REE:Leptin ratio, while derivative, may serve as a useful clinical indicator of changes in leptin sensitivity within obese subjects, and support the possibilities that hyperinsulinemia may be a proximate cause of leptin resistance, and that reduction of insulinema may promote weight loss by improving leptin sensitivity.
Journal ArticleDOI
A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
Robert H. Lustig,Frank L. Greenway,Pedro Velasquez-Mieyer,D Heimburger,D Schumacher,Diane K. Smith,W Smith,N Soler,Ghulam Warsi,William Berg,J Maloney,John Benedetto,W. Zhu,John Hohneker +13 more
TL;DR: It is indicated that Caucasian patients with the greater degree of insulin hypersecretion appeared to derive the most benefit from treatment, and the observed safety profile was consistent with the known effects of octreotide from previous studies.
Journal ArticleDOI
Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults.
Pedro Velasquez-Mieyer,Patricia A. Cowan,K. L. Arheart,K. L. Arheart,Cynthia K. Buffington,K. A. Spencer,B. E. Connelly,G. W. Cowan,Robert H. Lustig,Robert H. Lustig +9 more
TL;DR: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.
Journal ArticleDOI
Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects.
Pedro Velasquez-Mieyer,Patricia A. Cowan,Guillermo E. Umpierrez,Robert H. Lustig,Ann K. Cashion,George A. Burghen +5 more
TL;DR: It is indicated that obese AAs had higher concentrations of GLP-1 both at fasting and during the OGTT than obese C, which could explain the greater insulin concentration and the increased prevalence of hyperinsulinemia-associated disorders including obesity and type 2 diabetes in AAs.