Partners In Health

About: Partners In Health is a nonprofit organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Health care. The organization has 850 authors who have published 867 publications receiving 23805 citations. The organization is also known as: PIH.

WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update

Abstract: The production of guidelines for the management of drug-resistant tuberculosis (TB) fits the mandate of the World Health Organization (WHO) to support countries in the reinforcement of patient care. WHO commissioned external reviews to summarise evidence on priority questions regarding case-finding, treatment regimens for multidrug-resistant TB (MDR-TB), monitoring the response to MDR-TB treatment, and models of care. A multidisciplinary expert panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations. The recommendations support the wider use of rapid drug susceptibility testing for isoniazid and rifampicin or rifampicin alone using molecular techniques. Monitoring by sputum culture is important for early detection of failure during treatment. Regimens lasting ≥ 20 months and containing pyrazinamide, a fluoroquinolone, a second-line injectable drug, ethionamide (or prothionamide), and either cycloserine or p-aminosalicylic acid are recommended. The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens. Systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation. Scientific and medical associations should promote the recommendations among practitioners and public health decision makers involved in MDR-TB care. Controlled trials are needed to improve the quality of existing evidence, particularly on the optimal composition and duration of MDR-TB treatment regimens.

Surgery and global health: a view from beyond the OR

Abstract: In Africa, surgery may be thought of as the neglected stepchild of global public health. There are fewer physicians per population on this continent than on any other; surgeons are rarer still, and almost all of them work in the urban enclaves of what remains a rural region. The story is the same in the poorer parts of Asia and Latin America (with a few exceptions, such as Cuba). Although disease treatable by surgery remains a ranking killer of the world’s poor, major financers of public health have shown that they do not regard surgical disease as a priority even though, for example, more than 500,000 women die each year in childbirth; these deaths are largely attributable to an absence of surgical services and other means of stopping post-partum hemorrhage [1]. Equally unattended, among the very poor, are motor-vehicle and farm accidents, peritonitis, long-bone fractures, and even blindness [2-4]. Cardiac disease, congenital or the sequela of infection, is a death sentence for most people—many of them children— so afflicted in the poorest parts of the world [5, 6]. In some settings, surveys reveal that surgical disease is among the top 15 causes of disability [7], and surgical conditions account for up to 15% of total disability adjusted life years (DALYs) lost worldwide [8]. If it is true that surgery is the neglected stepchild of global health, does it follow that there are no surgical services available in the poor world? The truth is even more unpleasant: within poor countries, surgical services are concentrated almost wholly in cities and reserved largely for those who can pay for them. In Haiti, for example, a community-based survey conducted in the 1980s suggested that rates of caesarian section in a large area of southern Haiti were close to zero; maternal mortality was pegged at 1,400 per 100,000 live births [9]. Yet among the affluent of that same country, rates of caesarian section do not vary much from those registered in the United States. Careful scrutiny of local inequalities of risk and access to care reveals that in poor countries, even minor surgical pathologies are often transformed through time and inattention into lethal conditions. Congenital abnormalities such as cleft palate remain life-long afflictions rather than pediatric surgical disease. In addition to surgical abdomens, severe trauma (from road accidents more often than from intentional violence) and other potentially fatal pathologies remain a massive burden of untreated disease that weighs on the lives, and productivity, of the world’s bottom billion. P. E. Farmer (&) Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, Massachusetts 02115, USA e-mail: paul_farmer@hms.harvard.edu