L
Larry E. Kun
Researcher at St. Jude Children's Research Hospital
Publications - 339
Citations - 25388
Larry E. Kun is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Radiation therapy & Medulloblastoma. The author has an hindex of 80, co-authored 339 publications receiving 23821 citations. Previous affiliations of Larry E. Kun include University of Rochester Medical Center & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
Ching-Hon Pui,Dario Campana,Deqing Pei,W. Paul Bowman,John T. Sandlund,Sue C. Kaste,Raul C. Ribeiro,Jeffrey E. Rubnitz,Susana C. Raimondi,Mihaela Onciu,Elaine Coustan-Smith,Larry E. Kun,Sima Jeha,Cheng Cheng,Scott C. Howard,Vickey Simmons,Amy Bayles,Monika L. Metzger,James M. Boyett,Wing Leung,Rupert Handgretinger,James R. Downing,William E. Evans,Mary V. Relling +23 more
TL;DR: With effective risk-adjusted chemotherapy, prophylactic cranial irradiation can be safely omitted from the treatment of childhood ALL.
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Late neurocognitive sequelae in survivors of brain tumours in childhood.
TL;DR: Differences in cognitive development have been described most thoroughly among children treated for posterior-fossa tumours, specifically medulloblastomas and ependymomas, which account for about 30% of all newly diagnosed cases of brain tumours in children.
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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
Amar Gajjar,Murali Chintagumpala,David M. Ashley,Stewart J. Kellie,Larry E. Kun,Thomas E. Merchant,S.Y. Woo,Greg Wheeler,Valerie Ahern,Matthew J. Krasin,Maryam Fouladi,Alberto Broniscer,Robert A. Krance,Gregory A. Hale,Clinton F. Stewart,Robert C. Dauser,Robert A. Sanford,Christine E. Fuller,Ching C. Lau,James M. Boyett,Dana Wallace,Richard J. Gilbertson +21 more
TL;DR: Investigating the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma found it can be used to improve the outcome of patients with high-risk medullOBlastoma.
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Postoperative Chemotherapy and Delayed Radiation in Children Less Than Three Years of Age With Malignant Brain Tumors
Patricia K. Duffner,Marc E. Horowitz,Jeffrey P. Krischer,Henry S. Friedman,Peter C. Burger,Michael E. Cohen,Robert A. Sanford,Raymond K. Mulhern,Hector E. James,Carolyn R. Freeman,F. Glen Seidel,Larry E. Kun +11 more
TL;DR: Chemotherapy appears to be an effective primary postoperative treatment for many malignant brain tumors in young children and a comparison of cognitive evaluations obtained at base line and after one year of chemotherapy revealed no evidence of deterioration in cognitive function.
Journal ArticleDOI
Radiation response of the central nervous system.
TL;DR: It is suggested that the 5% incidence of radiation myelopathy probably lies between 57 and 61 Gy to the spinal cords in the absence of dose modifying chemotherapy, and a more pronounced volume effect is believed to exist in the brain than in the spinal cord.