Peeter Sikk

TL;DR: It is concluded that, in oxidative muscle cells, mitochondria are incorporated into functional complexes with adjacent ADP-producing systems in myofibrils and in sarcoplasmic reticulum, probably due to specific interaction with cytoskeletal elements responsible for mitochondrial distribution in the cell.

TL;DR: In this paper, the authors investigated the role of cytoskeletal proteins in the intracellular organization and control of mitochondria in the heart mitochondria and showed that the results show the rapid collapse of microtubular and plectin networks but not of desmin localization.

TL;DR: It is concluded that in oxidative muscle cells mitochondria behave as if they were incorporated into functional complexes with adjacent ADP producing systems - with the MgATPases in myofibrils and Ca,MgAtPases of sarcoplasmic reticulum.

TL;DR: Localized restrictions and heterogeneity of ADP diffusion demonstrate the importance of mitochondrial functional complexes with sarcoplasmic reticulum and myofibrillar structures and creatine kinase in regulation of oxidative phosphorylation.

TL;DR: Strong structural associations (functional complexes) among mitochondria, sarcomeres and sarcoplasmic reticulum are taken to show strong structural associations among mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures.