P
Peixin Dong
Researcher at Hokkaido University
Publications - 83
Citations - 3215
Peixin Dong is an academic researcher from Hokkaido University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 30, co-authored 62 publications receiving 2499 citations. Previous affiliations of Peixin Dong include Fukuoka University & Fudan University Shanghai Medical College.
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Journal ArticleDOI
Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
Peixin Dong,Mihriban Karaayvaz,Nan Jia,Masanori Kaneuchi,Jun-ichi Hamada,Hidemichi Watari,Satoko Sudo,Jingfang Ju,Noriaki Sakuragi +8 more
TL;DR: In this paper, the authors show that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to the promoter of miR130b (a negative regulator of ZEB1) and inhibiting its transcription.
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MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
Peixin Dong,Masanori Kaneuchi,Hidemichi Watari,Jun-ichi Hamada,Satoko Sudo,Jingfang Ju,Noriaki Sakuragi +6 more
TL;DR: The findings demonstrate the novel mechanism for BMI-1 in contributing to EC cell invasion and that repression of BMI- 1 by miR-194 could have a therapeutic potential to suppress EC metastasis.
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Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion.
TL;DR: The meta-analysis demonstrated that PD-L1 is co-amplified along with MYC, SOX2, N-cadherin and SNAI1 in the TCGA endometrial and ovarian cancer datasets, suggesting a possible immune evasion mechanism employed by cancer stem cells during metastasis.
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Emerging Therapeutic Biomarkers in Endometrial Cancer
TL;DR: The current status of molecular therapies tested in clinical trials are reviewed and the potential therapeutic candidates that are possibly used to develop more effective and specific therapies against endometrial cancer progression and metastasis are discussed.
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Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors.
Peixin Dong,Ying Xiong,Junming Yue,Sharon J.B. Hanley,Noriko Kobayashi,Yukiharu Todo,Hidemichi Watari +6 more
TL;DR: The latest insights into the expression pattern, biological roles and mechanisms underlying the function and regulation of NEAT1 in tumors are highlighted, and its clinical implication as a new diagnostic biomarker and an attractive therapeutic target for cancers is focused on.