P
Peng Liu
Researcher at University of Wolverhampton
Publications - 9
Citations - 1032
Peng Liu is an academic researcher from University of Wolverhampton. The author has contributed to research in topics: Cancer stem cell & Cancer. The author has an hindex of 7, co-authored 9 publications receiving 856 citations.
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Journal ArticleDOI
Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties.
Nga Chi Yip,Ivo S. Fombon,Peng Liu,Sarah Brown,Kannappan,Angel L. Armesilla,B Xu,Jim Cassidy,John L. Darling,Weiguang Wang +9 more
TL;DR: Disulfiram/copper inhibited BCSCs and enhanced cytotoxicity of PAC in BC cell lines and may be caused by simultaneous induction of ROS and inhibition of NFκB.
Journal ArticleDOI
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells.
Peng Liu,Sarah Brown,T Goktug,P. Channathodiyil,Vinodh Kannappan,J-P Hugnot,P-O Guichet,Xiu-Wu Bian,Angel L. Armesilla,John L. Darling,Weiguang Wang +10 more
TL;DR: The findings indicate that the cytotoxicity of DS/Cu and the enhancing effect ofDS/Cu on the cytOToxicity of dFdC in GBM stem-like cells may be caused by induction of ROS and inhibition of both ALDH and the NFkB pathway.
Journal ArticleDOI
Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
Peng Liu,I S Kumar,Sarah Brown,Vinodh Kannappan,Patricia Erebi Tawari,James Z. Tang,Wen Guo Jiang,Angel L. Armesilla,John L. Darling,Weiguang Wang +9 more
TL;DR: Disulfiram abolished CSC characters and completely reversed PAC and CDDP resistance in MDA-MB-231PAC10 cells, suggesting cancer stem cells may be responsible for acquired pan-chemoresistance.
Journal ArticleDOI
Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.
Peng Liu,Zhipeng Wang,Sarah Brown,Vinodh Kannappan,Patricia Erebi Tawari,Wenguo Jiang,Juan M. Irache,James Z. Tang,Stephen T. Britland,Angel L. Armesilla,John L. Darling,Weiguang Wang,Weiguang Wang Wang +12 more
TL;DR: A liposome-encapsulated DS (Lipo-DS) was developed and its anticancer effect and mechanisms in vitro and in vivo showed very strong anticancer efficacy and no significant in vivo nonspecific toxicity was observed.
Journal ArticleDOI
Simultaneous extraction and purification of alkaloids from Sophora flavescens Ait. by microwave-assisted aqueous two-phase extraction with ethanol/ammonia sulfate system
Wei Zhang,Dan Zhu,Huajun Fan,Huajun Fan,Xiaoqin Liu,Qiang Wan,Xuehao Wu,Peng Liu,James Z. Tang +8 more
TL;DR: In this article, a rapid and effective method of integrating extraction and purification for alkaloids from Sophora flavescens Ait was developed by microwave assisted aqueous two-phase extraction (MAATPE) based on the high efficiency of microwave-assisted extraction and the demixing effect of aaqueous two phase extraction (ATPE).