Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. ZnO is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination, ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), OH− (hydroxyl radicals), and O2 −2 (peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to ZnO-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions. These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on ZnO abrasive surface texture. One functional application of the ZnO antibacterial bioactivity was discussed in food packaging industry where ZnO-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of ZnO-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition.

/pdf/review-on-zinc-oxide-nanoparticles-antibacterial-activity-2smaigi8sc.pdf

Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism.

http://www.math.pku.edu.cn/teachers/xirb/Courses/UndergraduateThesis2014/1-s2.0-S0092867412007787-main.pdf

A landscape of driver mutations in melanoma

https://doc.rero.ch/record/29689/files/fro_apn.pdf

Antibacterial properties of nanoparticles.

Functional π-Gelators and Their Applications

Graphene is a single-atom thick, two-dimensional sheet of hexagonally arranged carbon atoms isolated from its three-dimensional parent material, graphite. Related materials include few-layer-graphene (FLG), ultrathin graphite, graphene oxide (GO), reduced graphene oxide (rGO), and graphene nanosheets (GNS). This review proposes a systematic nomenclature for this set of Graphene-Family Nanomaterials (GFNs) and discusses specific materials properties relevant for biomolecular and cellular interactions. We discuss several unique modes of interaction between GFNs and nucleic acids, lipid bilayers, and conjugated small molecule drugs and dyes. Some GFNs are produced as dry powders using thermal exfoliation, and in these cases, inhalation is a likely route of human exposure. Some GFNs have aerodynamic sizes that can lead to inhalation and substantial deposition in the human respiratory tract, which may impair lung defense and clearance leading to the formation of granulomas and lung fibrosis. The limited litera...

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

In this paper, we propose a novel encoder-decoder network, called Scale Aggregation Network (SANet), for accurate and efficient crowd counting. The encoder extracts multi-scale features with scale aggregation modules and the decoder generates high-resolution density maps by using a set of transposed convolutions. Moreover, we find that most existing works use only Euclidean loss which assumes independence among each pixel but ignores the local correlation in density maps. Therefore, we propose a novel training loss, combining of Euclidean loss and local pattern consistency loss, which improves the performance of the model in our experiments. In addition, we use normalization layers to ease the training process and apply a patch-based test scheme to reduce the impact of statistic shift problem. To demonstrate the effectiveness of the proposed method, we conduct extensive experiments on four major crowd counting datasets and our method achieves superior performance to state-of-the-art methods while with much less parameters.

/pdf/scale-aggregation-network-for-accurate-and-efficient-crowd-1krh4o874d.pdf

Scale Aggregation Network for Accurate and Efficient Crowd Counting

Polyvinyl alcohol (PVA) hydrogels have been proposed for use as promising biomaterials in biomedical and tissue engineering but their poor mechanical and water-retention properties have hindered their development. Graphene oxide (GO), an excellent nanofiller, was added to PVA to make GO/PVA composite hydrogels by a freeze/thaw method. The mechanical properties of the GO/PVA hydrogels were significantly improved. Compared to pure PVA hydrogels, a 132% increase in tensile strength and a 36% improvement of compressive strength were achieved with the addition of 0.8 wt% of GO, which suggests an excellent load transfer between the GO and the PVA matrix. The incorporation of certain amount of GO into composite hydrogels does not affect the toxicity of PVA to osteoblast cells.

High strength graphene oxide/polyvinyl alcohol composite hydrogels

Rho GTPase function in tumorigenesis.

The Visible Infrared Imaging Radiometer Suite (VIIRS) sensor aboard the Suomi National Polar-orbiting Partnership spacecraft has successfully operated since its launch in October 2011. The VIIRS collects data in 22 spectral bands that are calibrated by a set of onboard calibrators (OBC). In addition, lunar observations are made to independently track VIIRS long-term calibration stability for the reflective solar bands (RSB). This paper provides an overview of VIIRS OBC functions as well as its on-orbit operation and calibration activities. It also describes sensor calibration methodologies and demonstrates VIIRS on-orbit performance from launch to present. Results reported in this paper include on-orbit changes in sensor spectral band responses, detector noise characterization, and key calibration parameters. Issues identified and their potential impacts on sensor calibration are also discussed. Since launch, the VIIRS instrument nominal operation temperature has been stable to within ±1.0 K. The cold focal plane temperatures have been well controlled, with variations of less than 20 mK over a period of 1.5 years. In general, changes in thermal emissive bands (TEB) detector responses have been less than 0.5%. Despite large response degradation in several near-infrared and short-wave infrared bands and large SD degradation at short visible wavelengths, the VIIRS sensor and OBC overall performance has been excellent postlaunch. The degradation caused by the telescope mirror coating contamination has been modeled and its impact addressed through the use of modulated relative spectral response in the improved calibration and the current sensor data record data production. Based on current instrument characteristics and performance, it is expected that the VIIRS calibration will continue to meet its design requirements, including RSB detector signal to noise ratio and TEB detector noise equivalent temperature difference, throughout its 7 year design lifetime.

https://agupubs.onlinelibrary.wiley.com/doi/pdf/10.1002/2013JD020423

VIIRS on-orbit calibration methodology and performance

The antimicrobial activity of ZnO nanoparticles (NPs) was investigated under aquatic and aerosol exposure modes. ZnO NPs in aquatic media aggregated to micrometer-sized particles and did not interact with microorganisms effectively. Hence, the inhibition of microbial growth by nano-ZnO NPs (e.g., Mycobacterium smegmatis and Cyanothece 51142) in aquatic media was mainly attributable to dissolved zinc species. Shewanella oneidensis MR-1 and Escherichia coli were able to produce large amounts of extracellular polymeric substances, and their growth was not inhibited by ZnO NPs in aquatic media, even at high concentrations (>40 mg/L). On the other hand, when ZnO NPs were electrosprayed onto an E. coli biofilm so that NPs could be directly deposited onto the cell surface, the aerosol exposure dramatically reduced cellular viability. For example, an electrospray of ZnO NPs (20 nm) reduced the total number of viable E.coli cells by 57% compared to the control case, in which we electrosprayed only the buffer solution. However, electrospraying large-sized ZnO particles (480 nm) or nonsoluble TiO(2) NPs (20 nm) caused much less lethality to E. coli cells. The above observation implies that the aerosol method of exposing ZnO NPs to biological systems appears to have a much higher antimicrobial activity, and thus may lead to practical applications of employing a novel antimicrobial agent for airborne disease control.

Zhipeng Wang

Papers

Scale Aggregation Network for Accurate and Efficient Crowd Counting

High strength graphene oxide/polyvinyl alcohol composite hydrogels

Rho GTPase function in tumorigenesis.

VIIRS on-orbit calibration methodology and performance

Comparative Eco-Toxicities of Nano-ZnO Particles under Aquatic and Aerosol Exposure Modes