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Angel L. Armesilla
Researcher at University of Wolverhampton
Publications - 54
Citations - 3321
Angel L. Armesilla is an academic researcher from University of Wolverhampton. The author has contributed to research in topics: Plasma membrane Ca2+ ATPase & Signal transduction. The author has an hindex of 30, co-authored 52 publications receiving 2944 citations. Previous affiliations of Angel L. Armesilla include Autonomous University of Madrid & Spanish National Research Council.
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Journal ArticleDOI
Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties.
Nga Chi Yip,Ivo S. Fombon,Peng Liu,Sarah Brown,Kannappan,Angel L. Armesilla,B Xu,Jim Cassidy,John L. Darling,Weiguang Wang +9 more
TL;DR: Disulfiram/copper inhibited BCSCs and enhanced cytotoxicity of PAC in BC cell lines and may be caused by simultaneous induction of ROS and inhibition of NFκB.
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Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells.
Peng Liu,Sarah Brown,T Goktug,P. Channathodiyil,Vinodh Kannappan,J-P Hugnot,P-O Guichet,Xiu-Wu Bian,Angel L. Armesilla,John L. Darling,Weiguang Wang +10 more
TL;DR: The findings indicate that the cytotoxicity of DS/Cu and the enhancing effect ofDS/Cu on the cytOToxicity of dFdC in GBM stem-like cells may be caused by induction of ROS and inhibition of both ALDH and the NFkB pathway.
Journal ArticleDOI
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Kai Schuh,Elizabeth J. Cartwright,Eriks Jankevics,Karin Bundschu,Jürgen Liebermann,Judith C. Williams,Angel L. Armesilla,Michael Emerson,Delvac Oceandy,Klaus-Peter Knobeloch,Ludwig Neyses +10 more
TL;DR: It is shown that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility, supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca2+ levels.
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Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.
Angel L. Armesilla,Elisa Lorenzo,Pablo Gómez-del Arco,Sara Martínez-Martínez,Arantzazu Alfranca,Juan Miguel Redondo +5 more
TL;DR: NFAT was involved in the VEGF-mediated TF promoter activation as evidenced by cotransfection experiments with a dominant negative version of NFAT and site-directed mutagenesis of a newly identified NFAT site within the TF promoter that overlaps with a previously identified κB-like site.
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Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
Peng Liu,I S Kumar,Sarah Brown,Vinodh Kannappan,Patricia Erebi Tawari,James Z. Tang,Wen Guo Jiang,Angel L. Armesilla,John L. Darling,Weiguang Wang +9 more
TL;DR: Disulfiram abolished CSC characters and completely reversed PAC and CDDP resistance in MDA-MB-231PAC10 cells, suggesting cancer stem cells may be responsible for acquired pan-chemoresistance.