P
Pengyang Zhu
Researcher at Harbin Veterinary Research Institute
Publications - 4
Citations - 208
Pengyang Zhu is an academic researcher from Harbin Veterinary Research Institute. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 3, co-authored 4 publications receiving 157 citations.
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Journal ArticleDOI
The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks
Jiasheng Song,Huapeng Feng,Jing Xu,Dongming Zhao,Jianzhong Shi,Yanbing Li,Guohua Deng,Yongping Jiang,Xuyong Li,Pengyang Zhu,Yuntao Guan,Zhigao Bu,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Hualan Chen +14 more
TL;DR: It is shown that the polymerase PA subunit is a virulence factor for H5N1 AIVs in ducks, and substitution of two amino acids, S224P and N383D, in PA contributed to the highly virulent phenotype.
Journal ArticleDOI
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Weiyu Luo,Jie Zhang,Libin Liang,Guangwen Wang,Qibing Li,Pengyang Zhu,Yuan Zhou,Junping Li,Yuhui Zhao,Nan Sun,Shanyu Huang,Chenchen Zhou,Yu Chang,Pengfei Cui,Pucheng Chen,Yongping Jiang,Guohua Deng,Zhigao Bu,Chengjun Li,Li Jiang,Hualan Chen +20 more
TL;DR: It is found that the stable overexpression of PLSCR1 suppressed the nuclear import of NP, hindered the virus life cycle, and significantly inhibited the replication of various influenza subtypes.
Journal ArticleDOI
Host cellular protein TRAPPC6AΔ interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking
Pengyang Zhu,Libin Liang,Xinyuan Shao,Weiyu Luo,Shuitao Jiang,Qingqing Zhao,Nan Sun,Yuhui Zhao,Junping Li,Jinguang Wang,Yuan Zhou,Jie Zhang,Guangwen Wang,Li Jiang,Hualan Chen,Chengjun Li +15 more
TL;DR: The results indicated that TRAPPC6AΔ, through its interaction with M2, slows M2 trafficking to the apical plasma membrane, favors viral replication in vitro, and positively modulates virus virulence in mice.
Journal ArticleDOI
Transcriptomic analyses reveal new genes and networks response to H5N1 influenza viruses in duck (Anas platyrhynchos)
Yinhua Huang,Huapeng Feng,Li-ren Huang,Kang Yi,Enguang Rong,Xiaoyun Chen,Jian-wen Li,Zeng Wang,Pengyang Zhu,Xiaojuan Liu,Xiaoxue Wang,Jia-xiang Hu,Xin Liu,Hualan Chen,Jun Wang,Ning Li +15 more
TL;DR: It is found that both H5N1 virus strains might escape or subvert host immune response through affectingAlternative translation of immune genes, while the DK/49 virus seemed to induce alternative translation of more immune genes than the GS/65 virus.