P
Penny Timms
Researcher at University of Bristol
Publications - 4
Citations - 21
Penny Timms is an academic researcher from University of Bristol. The author has contributed to research in topics: Colorectal cancer & Homologous recombination. The author has an hindex of 1, co-authored 2 publications receiving 8 citations.
Papers
More filters
Journal ArticleDOI
The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis
Danny Legge,Adam C. Chambers,Christopher Parker,Penny Timms,Tracey J Collard,Ann C. Williams +5 more
TL;DR: It is suggested that targeting BCL-3 could increase the tumour response to conventional treatment, reduce the chance of relapse and hence improve the prognosis for cancer patients.
Posted ContentDOI
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
Amy K. Holt,Arafath Kaja Najumudeen,Ashley J. Hoskin,Danny Legge,Eleanor. Mortensson,Dustin J. Flanagan,Nicholas Jones,Madhu Kollareddy,Tracey J Collard,Penny Timms,Owen J. Sansom,Ann C. Williams,Emma E. Vincent +12 more
TL;DR: It is shown that aspirin leads to significant metabolic reprogramming in colorectal cancer cells and raises the possibility that aspirin could significantly increase the efficacy of metabolic cancer therapies in CRC.
Posted ContentDOI
Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination
Christopher Parker,Adam C. Chambers,Dustin J. Flanagan,Tracey J Collard,Greg H.P. Ngo,Duncan M. Baird,Penny Timms,Rhys G. Morgan,Owen J. Sansom,Ann C. Williams +9 more
TL;DR: The findings offer a rationale for targeting BCL-3 in CRC as an adjuvant to conventional therapies and suggest that Bcl-3 expression in tumours could be a useful biomarker in stratification of rectal cancer patients for neo-adjuvant chemoradiotherapy.
Journal ArticleDOI
BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination.
Christopher Parker,Adam C. Chambers,Dustin J. Flanagan,Jasmine Wing Yu Ho,Tracey J Collard,Greg H.P. Ngo,Duncan M. Baird,Penny Timms,Rhys G. Morgan,Owen J. Sansom,Ann C. Williams +10 more
TL;DR: In this article , the role of BCL-3 in determining therapeutic response remains largely unknown, although increased expression correlates with poor patient prognosis, the authors use combined approaches in multiple cell lines and pre-clinical mouse models to investigate the function of the proto-oncogene in the DNA damage response.