P
Pepper Schedin
Researcher at Oregon Health & Science University
Publications - 139
Citations - 6867
Pepper Schedin is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 39, co-authored 122 publications receiving 5848 citations. Previous affiliations of Pepper Schedin include University of Colorado Boulder & University of Colorado Hospital.
Papers
More filters
Journal ArticleDOI
Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression
Pepper Schedin,Patricia J. Keely +1 more
TL;DR: Understanding the role of forces in the mammary gland is crucial to understanding both normal developmental and pathological processes.
Journal ArticleDOI
Pregnancy-associated breast cancer and metastasis
TL;DR: The mammary microenvironment might become tumour-promoting after pregnancy because of the remodelling of the mammary gland to its pre-pregnant state, and this remodelling, which is associated with pro-inflammatory and wound-healing mechanisms, is proposed to support tumours dissemination.
Journal ArticleDOI
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2
Traci R. Lyons,Jenean O'Brien,Virginia F. Borges,Virginia F. Borges,Matthew W. Conklin,Patricia J. Keely,Kevin W. Eliceiri,Andriy Marusyk,Aik Choon Tan,Aik Choon Tan,Pepper Schedin,Pepper Schedin +11 more
TL;DR: A mouse model of postpartum breast cancer that identifies mammary gland involution as a driving force of tumor progression is described and data support further research to determine whether women at high risk for postpartums breast cancer would benefit from treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) during post partum involution.
Journal ArticleDOI
Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species
Jenean O'Brien,Traci R. Lyons,Jenifer Monks,M. Scott Lucia,M. Scott Lucia,R. Storey Wilson,Lisa M. Hines,Yan Gao Man,Virginia F. Borges,Virginia F. Borges,Pepper Schedin +10 more
TL;DR: Fibrillar collagen levels and proteolysis increased dramatically during involution, and denatured collagen I acted as a strong chemoattractant for macrophages in cell culture, suggesting proteolyzed fibrillsar collagen as a candidate ECM mediator of macrophage recruitment.
Journal ArticleDOI
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis.
Shauntae M. McDaniel,Kristen K. Rumer,Sandra L. Biroc,Richard P. Metz,Meenakshi Singh,Weston Porter,Pepper Schedin +6 more
TL;DR: It is suggested that the mammary gland microenvironment becomes promotional for tumor cell dissemination during involution, thus providing a plausible mechanism to explain the high rate of metastases that occur with pregnancy-associated breast cancer.