W
Weston Porter
Researcher at Texas A&M University
Publications - 67
Citations - 3993
Weston Porter is an academic researcher from Texas A&M University. The author has contributed to research in topics: Estrogen receptor & Cancer. The author has an hindex of 32, co-authored 59 publications receiving 3775 citations. Previous affiliations of Weston Porter include University of Texas Southwestern Medical Center & University of Western Ontario.
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Journal ArticleDOI
Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor
TL;DR: The results illustrate a new estrogen-dependent transactivation pathway that involves ER-protein interactions and is ERE-independent, whereas transactivation of promoter-reporter constructs is estrogen- dependent.
Journal Article
A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity
Nanjoo Suh,Yongping Wang,Tadashi Honda,Gordon W. Gribble,Ethan Dmitrovsky,William F. Hickey,Robert A. Maue,Andrew E. Place,Donna M. Porter,Michael J. Spinella,Charlotte R. Williams,Gengfei Wu,Andrew J. Dannenberg,Kathleen C. Flanders,John J. Letterio,David J. Mangelsdorf,Carl Nathan,Lananh Nguyen,Weston Porter,Renee F. Ren,Anita B. Roberts,Nanette S. Roche,Kotha Subbaramaiah,Michael B. Sporn +23 more
TL;DR: The results suggest that CDDO needs further study in vivo, for either chemoprevention or chemotherapy of malignancy as well as for neuroprotection.
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Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms
TL;DR: Results indicate that the nuclear AhR complex targets specific genomic core inhibitory dioxin responsive elements (iDREs) in promoter regions of some E2-responsive target genes to inhibit hormone-induced transactivation.
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Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
TL;DR: Electrophoretic mobility shift assays demonstrate that Ah receptor-mediated inhibition of E2-induced cathepsin D gene expression is due to disruption of the ER-Sp1 complex by targeted interaction with an overlapping XRE.
Journal ArticleDOI
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis.
Shauntae M. McDaniel,Kristen K. Rumer,Sandra L. Biroc,Richard P. Metz,Meenakshi Singh,Weston Porter,Pepper Schedin +6 more
TL;DR: It is suggested that the mammary gland microenvironment becomes promotional for tumor cell dissemination during involution, thus providing a plausible mechanism to explain the high rate of metastases that occur with pregnancy-associated breast cancer.