Per Hellman

TL;DR: An inherited KCNJ5 mutation that produces increased Na+ conductance in a Mendelian form of severe aldosteronism and massive bilateral adrenal hyperplasia is identified, explaining pathogenesis in a subset of patients with severe hypertension and implicate loss of K+ channel selectivity in constitutive cell proliferation and hormone production.

TL;DR: De novo germline mutations at identical positions in two children with a previously undescribed syndrome featuring primary aldosteronism and neuromuscular abnormalities are identified and implicate gain-of-function Ca2+ channel mutations in APAs and primary a Aldosterone-producing adenomas.

TL;DR: Plasma PTH levels predict cardiovascular mortality in the community, even in individuals with PTH within the normal range, and whether PTH is a modifiable risk factor is investigated.

TL;DR: Surgery to remove the primary intestinal tumor including mesenteric lymph node metastases is supported by the present results, even in the presence of liver metastases, which are identified as major negative prognostic factors for survival.

TL;DR: Both high and low concentrations of plasma 25(OH)D are associated with elevated risks of overall and cancer mortality.