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Perumal Sivashanmugam
Researcher at University of North Carolina at Chapel Hill
Publications - 17
Citations - 1163
Perumal Sivashanmugam is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Gene & Messenger RNA. The author has an hindex of 17, co-authored 17 publications receiving 1117 citations. Previous affiliations of Perumal Sivashanmugam include Merck & Co. & Duke University.
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Journal ArticleDOI
Reversible immunocontraception in male monkeys immunized with eppin.
Michael G. O'Rand,Esther E. Widgren,Perumal Sivashanmugam,Richard T. Richardson,Susan H. Hall,Frank S. French,C. A. VandeVoort,S. G. Ramachandra,V. Ramesh,A. Jagannadha Rao +9 more
TL;DR: This study demonstrates that effective and reversible male immunocontraception is an attainable goal and may be extended to humans.
Journal ArticleDOI
Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis.
Richard T. Richardson,Perumal Sivashanmugam,Susan H. Hall,Katherine G. Hamil,Paul A. Moore,Steven M. Ruben,Frank S. French,Michael G. O'Rand +7 more
TL;DR: Eppin represents the first member of a family of protease inhibitors characterized by dual inhibitor consensus sequences, both WAP-type and Kunitz-type consensus sequences.
Journal ArticleDOI
Expression of Tumor Necrosis Factor Receptor-1 in Arterial Wall Cells Promotes Atherosclerosis
Lisheng Zhang,Karsten Peppel,Perumal Sivashanmugam,Eric S. Orman,Leigh Brian,Sabrina T. Exum,Neil J. Freedman +6 more
TL;DR: TNFR1 signaling contributes to the pathogenesis of atherosclerosis by enhancing arterial wall chemokine and adhesion molecule expression, as well as by augmenting medial smooth muscle cell proliferation and migration.
Journal ArticleDOI
Antimicrobial Activity of Human EPPIN, an Androgen-Regulated, Sperm-Bound Protein with a Whey Acidic Protein Motif
Suresh Yenugu,Richard T. Richardson,Perumal Sivashanmugam,Zengjun Wang,Michael G. O'Rand,Frank S. French,Susan H. Hall +6 more
TL;DR: The results indicate that EPPIN has a role in the innate immune system of human epididymis, and the importance of disulfide bonds for its activity is indicated.
Journal ArticleDOI
HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.
Katherine G. Hamil,Perumal Sivashanmugam,Richard T. Richardson,Gail Grossman,Steven M. Ruben,James L. Mohler,Peter Petrusz,Michael G. O'Rand,Frank S. French,Susan H. Hall +9 more
TL;DR: It is revealed that the 0.9-kb messenger RNA (mRNA) is most abundant in human caput; there is much less of it in corpus and little in cauda; and testosterone replacement maintained HE2 mRNA 3- to 5-fold higher than castrate levels, indicating its androgen dependence.