P
Peter B. Hedlund
Researcher at Scripps Research Institute
Publications - 72
Citations - 4475
Peter B. Hedlund is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 33, co-authored 72 publications receiving 4254 citations. Previous affiliations of Peter B. Hedlund include Karolinska Institutet.
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Descending command systems for the initiation of locomotion in mammals.
TL;DR: 5-HT neurons located in the parapyramidal region (PPR) constitute the first anatomically discrete group of spinally-projecting neurons demonstrated to be involved in the initiation of locomotion in mammals, and it is concluded that the PPR is the source of a descending 5-HT command pathway that activates the CPG via 7-HT(7) and 5- HT(2A) receptors.
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Functional, molecular and pharmacological advances in 5-HT7 receptor research
TL;DR: Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established, suggesting that this receptor might be involved in mood regulation and putative target in the treatment of depression.
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Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo
Atheir I. Abbas,Peter B. Hedlund,Xi Ping Huang,Thuy B. Tran,Herbert Y. Meltzer,Bryan L. Roth +5 more
TL;DR: It is discovered that amisulpride was a potent competitive antagonist at 5-HT7a receptors and that interactions with no other molecular target investigated in this paper could explain its antidepressant actions in vivo.
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5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern
TL;DR: The 5-HT7 receptor might have a role in mood disorders and antagonists might have therapeutic value as antidepressants, suggesting that it utilizes an independent mechanism.
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The 5-HT7 receptor and disorders of the nervous system: an overview.
TL;DR: The use of pharmacological and genetic tools in preclinical animal models strongly supports a role for the 5-HT7 receptor in depression and indirect evidence exists showing that 5- HT7 receptor antagonism is clinically useful in the treatment of depression.