Showing papers by "Peter Buneman published in 2015"
TL;DR: The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties.
Abstract: The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13347/full. This compilation of the major pharmacological targets is divided into eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
255 citations
14 Jan 2015
TL;DR: Over the same period, some interesting new connections between databases and programming languages have emerged, notably in the areas of scientific databases, annotation and provenance, and should programming language research have anything to contribute to these new languages?
Abstract: The 1990s saw a hugely productive interaction between database and programming language research. Ideas about type systems from programming languages played a central role in generalizing and adapting relational database systems to new data models. At the same time databases provided some of the best concrete examples of the application of concurrency theory and of the benefits of high-level optimization in functional programming languages. One of the driving ambitions behind this research was the idea that database access should be properly embedded in programming languages: one should not have to be bilingual in order to use a database from a programming language; and that goal has to some extent been realized. In the past fifteen years, new data models, both for data storage and for data exchange have appeared with depressing regularity and with each such model, the inevitable query language. Does programming language research have anything to contribute to these new languages? Should we take the time to to worry about embedding these models in conventional languages? Over the same period, some interesting new connections between databases and programming languages have emerged, notably in the areas of scientific databases, annotation and provenance. Will this provide new opportunities for cross-fertilization?
1 citations