Showing papers by "Peter C. Burger published in 2009"

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Open Access

Journal Article•DOI•

Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo.

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Yu-Tzu Tai¹, Kihyun Kim², Xian-Feng Li¹, Mariateresa Fulciniti¹, Weihua Song¹, Sabikun Nahar¹, Peter C. Burger¹, Mathew J. Rumizen¹, Klaus Podar¹, Dharminder Chauhan¹, Teru Hideshima¹, Robert L. Schlossman¹, Nikhil C. Munshi¹, Paul G. Richardson¹, Ann M. Clark³, Janet Ogden³, Goutopoulos Andreas³, Luca Rastelli³, Kenneth C. Anderson¹ - Show less +15 more•Institutions (3)

Harvard University¹, Samsung Medical Center², Merck Serono³

20 Nov 2009-Blood

TL;DR: Chauhan et al. as discussed by the authors investigated the cytotoxicity of AS703026, a selective MEK1/2 inhibitor with highly oral bioavailability, in MM cell lines and patient MM cells and defined its mechanisms of action.

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3 citations