P
Peter C. M. Molenaar
Researcher at Queensland University of Technology
Publications - 559
Citations - 22056
Peter C. M. Molenaar is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Acetylcholine & Myasthenia gravis. The author has an hindex of 72, co-authored 548 publications receiving 20418 citations. Previous affiliations of Peter C. M. Molenaar include Baker IDI Heart and Diabetes Institute & Leiden University.
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The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology
TL;DR: Non-conventional partial agonists may be beneficial for the treatment of peripheral autonomic neuropathy but probably due to their arrhythmic propensities, may be harmful for the Treatment of chronic heart failure.
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Individual differences in P300 amplitude : a genetic study in adolescent twins
TL;DR: Using quantitative genetic research designs, phenotypic variance in P300 parameters was decomposed into genetic and environmental components using the twin method and the covariance of the P300 amplitude measured at different locations was attributable both to unshared environmental and to shared factors.
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(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β1-adrenoceptor
Doreen Sarsero,Fraser D. Russell,James A. Lynham,G. C. Rabnott,Ian A. Yang,Kwun M. Fong,Li Li,Alberto J. Kaumann,Peter C. M. Molenaar +8 more
TL;DR: It is shown that (-)-CGP 12177 increases contractility and hastens relaxation through a cyclic AMP pathway in human myocardium, consistent with mediation through a (-)-propranolol-resistant state of the β1-adrenoceptor.
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Putative β4-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (−)-[3H]-CGP 12177 binding
Doreen Sarsero,Peter C. M. Molenaar,Peter C. M. Molenaar,Alberto J. Kaumann,Alberto J. Kaumann,Nicholas S. Freestone +5 more
TL;DR: The agreement of binding affinities of agonists with cardiostimulant potencies is consistent with mediation through putative β4‐adrenoceptors labelled with (−)‐[3H]‐CGP 12177, suggesting coupling to Gs protein‐adenylyl cyclase.
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An analysis of acetylcholine in frog muscle by mass fragmentography
TL;DR: Extracts of frog sartorius muscles were assayed for their acetylcholine (ACh) content by means of pyrolysis-gas chromatography/mass spectrometry and it was concluded that there is about 12 pmol extraneural ACh in sartorian muscle, and that about 30 pmol is in the nerve terminals.