P
Peter C. Whybrow
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 183
Citations - 10544
Peter C. Whybrow is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Bipolar disorder & Mood. The author has an hindex of 47, co-authored 176 publications receiving 9643 citations. Previous affiliations of Peter C. Whybrow include University of Pennsylvania & University of California, Los Angeles.
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Journal ArticleDOI
The thyroid-brain interaction in thyroid disorders and mood disorders.
TL;DR: This work reviews the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders and investigates the role of thyroid hormone in the adult brain.
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Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement.
TL;DR: With such extensive previous study one might question the purpose of a further evaluation of the mental changes occurring in thyroid gland dysfunction, and it is opinion, however, that much remains to be clarified.
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Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain.
TL;DR: There is robust evidence, particularly from animal studies, that the thyroid economy has a modulating impact on the brain serotonin system, and one mechanism is postulated through which exogenous thyroid hormones may exert their modulatory effects in affective illness is via an increase in serotonergic neurotransmission.
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Abnormalities of Indoleamines in Affective Disorders
TL;DR: Examining the concentration of 5HIAA in the lumbar CSF of patients suffering from affec¬ tive disorders found increasing evidence of an abnormality of indoleamines in the affective disorders, though the probenecid test showed evidence of decreased rate of 5-HT synthesis in these conditions.
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World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, part 1: acute and continuation treatment of major depressive disorder
TL;DR: These guidelines were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP) as discussed by the authors, and were intended for use by all physicians seeing and treating patients with these conditions.