P
Peter Caravan
Researcher at Harvard University
Publications - 254
Citations - 17399
Peter Caravan is an academic researcher from Harvard University. The author has contributed to research in topics: Magnetic resonance imaging & Fibrosis. The author has an hindex of 52, co-authored 226 publications receiving 15104 citations. Previous affiliations of Peter Caravan include University of Leicester & University of Arizona.
Papers
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Journal ArticleDOI
Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
TL;DR: A. Relaxivity 2331 E. Outerand Second-Sphere relaxivity 2334 F. Methods of Improving Relaxivity 2336 V. Macromolecular Conjugates 2336.
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Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.
TL;DR: This tutorial review describes the molecular factors that contribute to relaxivity and illustrates with recent examples how these can be optimized.
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Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
TL;DR: This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety and efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives.
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Biodistribution of gadolinium-based contrast agents, including gadolinium deposition.
Silvio Aime,Peter Caravan +1 more
TL;DR: The biodistribution of approved gadolinium (Gd)‐based contrast agents (GBCAs) is reviewed and very small amounts of Gd are retained in the bone and liver, and the amount retained correlates with the kinetic and thermodynamic stability of the GBCA with respect to Gd release in vitro.
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Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents.
TL;DR: Simulations were performed to understand the relative contributions of molecular parameters to longitudinal (r(1) and transverse) relaxivity as a function of applied field, and to obtain theoretical relaxivity maxima over a range of fields to appreciate what relaxivities can be achieved experimentally.