Peter Chiba

TL;DR: A set of propafenonetype substrate photoaffinity ligands has been used in this study in conjunction with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to define the substrate binding domain(s) of P-gp in more detail, and binding at domain interfaces may be a general feature of polyspecific drug efflux pumps.

TL;DR: This review will mainly focus on MDR-associated proteins, as well as various nanoparticle formulations developed to overcome MDR in breast cancer.

TL;DR: Mass cultures of primary murine erythroid progenitors from fetal liver suggest that highly efficient utilization of iron in mitochondrial heme synthesis during normal erythropoiesis alters the regulation of iron metabolism via the IRE/IRP system.

TL;DR: KP772 is hyperactive in MDR cells and might have chemosensitizing properties by blocking ABCB1 expression, and the data suggest that KP772 should be especially active against notoriously drug-resistant tumor types and as second line treatment after standard chemotherapy failure.

TL;DR: Docking studies of selected analogues into a homology model of P-glycoprotein suggest that benzophenones show an interaction pattern similar to that previously identified for propafenone-type inhibitors.