P
Peter F. Leadlay
Researcher at University of Cambridge
Publications - 261
Citations - 14540
Peter F. Leadlay is an academic researcher from University of Cambridge. The author has contributed to research in topics: Polyketide synthase & Polyketide. The author has an hindex of 64, co-authored 257 publications receiving 13869 citations. Previous affiliations of Peter F. Leadlay include Monash University, Clayton campus & Laboratory of Molecular Biology.
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Journal ArticleDOI
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.
TL;DR: A novel organization of the erythromycin-producing polyketide synthase is revealed, which provides further insight into the mechanism of chain assembly.
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How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.
Filippo Mancia,Nicholas H. Keep,Atsushi Nakagawa,Peter F. Leadlay,Sean McSweeney,Bjarne F. Rasmussen,Peter Bö secke,Olivier Diat,Philip R. Evans +8 more
TL;DR: The histidine-cobalt distance is very long, suggesting that the enzyme positions the histidine in order to weaken the metal-carbon bond of the cofactor and favour the formation of the initial radical species.
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Combinatorial biosynthesis of reduced polyketides
TL;DR: The bacterial multienzyme polyketide synthases produce a diverse array of products that have been developed into medicines, including antibiotics and anticancer agents, but key challenges remain before the potential of combinatorial biosynthesis can be fully realized.
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Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
Markiyan Oliynyk,Markiyan Samborskyy,J. B. Lester,Tatiana Mironenko,Nataliya Scott,Shilo Dickens,Stephen F. Haydock,Peter F. Leadlay +7 more
TL;DR: The availability of the genome sequence of S. erythraea will improve insight into its biology and facilitate rational development of strains to generate high-titer producers of clinically important antibiotics.
Journal ArticleDOI
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
Timothy P. Stinear,Armand Mve-Obiang,Pamela L. C. Small,Wafa Frigui,Melinda J. Pryor,Roland Brosch,Grant A. Jenkin,Paul D R Johnson,John K. Davies,Richard E. Lee,Sarojini Adusumilli,Thierry Garnier,Stephen F. Haydock,Peter F. Leadlay,Stewart T. Cole +14 more
TL;DR: It is shown that MU contains a 174-kb plasmid, pMUM001, bearing a cluster of genes encoding giant polyketide synthases (PKSs), and polyketid-modifying enzymes, and demonstrated that these are necessary and sufficient for mycolactone synthesis.