P
Peter H. Dube
Researcher at University of Texas Health Science Center at San Antonio
Publications - 56
Citations - 2728
Peter H. Dube is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Yersinia enterocolitica & Immune system. The author has an hindex of 24, co-authored 53 publications receiving 2276 citations. Previous affiliations of Peter H. Dube include Washington University in St. Louis & University of Texas at Austin.
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Journal ArticleDOI
Activation of innate immune antiviral responses by Nod2
Ahmed Sabbah,Te Hung Chang,Rosalinda Harnack,Victoria Frohlich,Kaoru Tominaga,Peter H. Dube,Yan Xiang,Santanu Bose +7 more
TL;DR: The function of Nod2 as a viral PRR highlights the important function ofNod2 in host antiviral defense mechanisms.
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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
Michael Dominic Sacco,Chunlong Ma,Panagiotis Lagarias,Ang Gao,Julia Alma Townsend,Xiangzhi Meng,Peter H. Dube,Xiujun Zhang,Yanmei Hu,Naoya Kitamura,Brett L. Hurst,Bart Tarbet,Michael T. Marty,Antonios Kolocouris,Yan Xiang,Yu Chen,Jun Wang +16 more
TL;DR: The structure of Mpro with calpain inhibitor II confirmed that the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a Hydrophilic residue is necessary at this position.
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Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Norberto Gonzalez-Juarbe,Norberto Gonzalez-Juarbe,Ryan P. Gilley,Cecilia A. Hinojosa,Cecilia A. Hinojosa,Kelley M. Bradley,Akinobu Kamei,Geli Gao,Peter H. Dube,Molly A. Bergman,Carlos J. Orihuela,Carlos J. Orihuela +11 more
TL;DR: The mechanisms for PFT-induced necroptosis were explored and it was determined that loss of ion homeostasis at the plasma membrane, mitochondrial damage, ATP depletion, and the generation of reactive oxygen species were together responsible.
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A MyD88-Dependent Early IL-17 Production Protects Mice against Airway Infection with the Obligate Intracellular Pathogen Chlamydia muridarum
Xiaoyun Zhang,Lifen Gao,Lei Lei,Youmin Zhong,Peter H. Dube,Michael T. Berton,Bernard P. Arulanandam,Jinshun Zhang,Guangming Zhong +8 more
TL;DR: It is suggested that an early IL-17 response as an innate immunity component plays an important role in initiating host defense against infection with intracellular bacterial pathogens in the airway.
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Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor
TL;DR: Results suggest that sequences surrounding Pro-258 may be involved in ligand activation of the alpha-factor pheromone receptor, and conformational changes in transmembrane domain 6 may effect a change in the adjacent sequences in the third intracellular loop that are thought to function in G protein activation.