P
Peter H. Schafer
Researcher at Celgene
Publications - 208
Citations - 10746
Peter H. Schafer is an academic researcher from Celgene. The author has contributed to research in topics: Lenalidomide & Apremilast. The author has an hindex of 52, co-authored 204 publications receiving 9683 citations.
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Journal ArticleDOI
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Antonia Lopez-Girona,Derek Mendy,Takumi Ito,Karen Miller,Anita Gandhi,Jian Kang,Satoki Karasawa,Gilles Carmel,Pilgrim Jackson,Mahan Abbasian,Afshin Mahmoudi,Brian E. Cathers,Emily Rychak,Svetlana Gaidarova,Roger Shen-Chu Chen,Peter H. Schafer,Hiroshi Handa,Thomas O. Daniel,Jilly F. Evans,Rajesh Chopra +19 more
TL;DR: Biophysical, biochemical and gene silencing studies show that CRBN is a proximate, therapeutically important molecular target of lenalidomid and pomalidomide.
Journal ArticleDOI
Keynote review: Phosphodiesterase-4 as a therapeutic target
TL;DR: The range of PDE4 isoforms, their role in signaling, their structural biology and related preclinical and clinical pharmacology are delineated, to provide potential, novel therapeutics for the treatment of inflammatory diseases and psoriasis.
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Prolonged Bacterial Culture to Identify Late Periprosthetic Joint Infection: A Promising Strategy
TL;DR: In both populations, an unequivocal correlation between the number of culture-positive tissue samples and positive results of histologic analysis was noted, which corroborated the evidence that true infections were detected over the entire cultivation period.
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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
Anita Gandhi,Jian Kang,Courtney G. Havens,Thomas Conklin,Yuhong Ning,Lei Wu,Takumi Ito,Hideki Ando,Michelle Waldman,Anjan Thakurta,Anke Klippel,Hiroshi Handa,Thomas O. Daniel,Peter H. Schafer,Rajesh Chopra +14 more
TL;DR: This work presents a molecular model in which drug binding to cereblon results in the interaction of Ikaros and Aiolos to CRL4CRBN, leading to their ubiquitination, subsequent proteasomal degradation and T cell activation.
Journal ArticleDOI
Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20+ Tumor Cells
Lei Wu,Mary Adams,Troy Carter,Roger Shen-Chu Chen,George W. Muller,David I. Stirling,Peter H. Schafer,J. Blake Bartlett +7 more
TL;DR: It is suggested that lenalidomide has the potential to enhance the rituximab-induced killing of NHL cell lines and primary B-cell chronic lymphocytic leukemia cells via a NK cell-mediated and monocyte-mediated ADCC mechanism in vitro, providing a strong rationale for the combination of lenalidumide with IgG1 antibodies to target tumor-specific antigens in patients with cancer.