Peter H. Schafer

TL;DR: It is reported that lenalidomide inhibits proliferation of chromosome 5 deleted hematopoietic tumor cell lines in vitro, whether from the B cell, T cell, or myeloid lineage, and evidence for the mechanism of action is provided.

TL;DR: Using cementless prostheses in two-stage revisions of periprosthetic infections of the hip in combination with a specific local and systemic antibiotic therapy seems to eradicate infection and provide implant stability.

TL;DR: The three-drug combination was able halt the progression of tumor growth almost completely in xenograft models of ocular melanoma, colon cancer, pancreatic cancer, and cutaneous melanoma and shows great promise for use in the clinic.

TL;DR: It is demonstrated that C/EBPβ protein expression is under eIF4E-translational control in MM and targeting translation at a different level by inhibiting eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation overcame resistance, suggesting that this pathway is critical and might be a target to overcome drug resistance.

TL;DR: The results of this phase II, multicenter, open-label study confirm apremilast's biological and clinical activity and support ongoing studies in psoriasis.