P
Peter Henrik Andersen
Researcher at Statens Serum Institut
Publications - 102
Citations - 13138
Peter Henrik Andersen is an academic researcher from Statens Serum Institut. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 44, co-authored 102 publications receiving 12612 citations. Previous affiliations of Peter Henrik Andersen include Stanford University & University of Oslo.
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Specific immune-based diagnosis of tuberculosis
TL;DR: Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response similar to that induced by infection with Mycobacterium tuberculosis.
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The success and failure of BCG - implications for a novel tuberculosis vaccine.
TL;DR: The potential mechanisms behind the variation of BCG efficacy and their implications for an improved TB vaccination strategy are discussed.
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Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak
Katie J. Ewer,Jonathan J Deeks,Lydia Alvarez,Gerry Bryant,Sue Waller,Peter Henrik Andersen,Philip Monk,Ajit Lalvani +7 more
TL;DR: A sensitive enzyme-linked immunospot (ELISPOT) assay to detect T cells specific for Mycobacterium tuberculosis antigens that are absent from Myc Cobacterium bovis BCG and most environmental mycobacteria that could improve tuberculosis control by more precise targeting of preventive treatment.
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Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.
TL;DR: A novel immunogenic antigen, the 6-kDa early secretory antigenic target (ESAT-6), from short-term culture filtrates of Mycobacterium tuberculosis was purified by hydrophobic interaction chromatography and anion-exchange chromatography by use of fast protein liquid chromatography.
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Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.
TL;DR: Southern blotting and PCR experiments with genomic mycobacterial DNA showed the presence of the esat-6 gene in reference strains and clinical isolates of M. tuberculosis as well as in virulent M. bovis BCG.