P
Peter J. Gaskill
Researcher at Drexel University
Publications - 42
Citations - 1501
Peter J. Gaskill is an academic researcher from Drexel University. The author has contributed to research in topics: Dopamine & Medicine. The author has an hindex of 16, co-authored 27 publications receiving 1119 citations. Previous affiliations of Peter J. Gaskill include Yeshiva University & Scripps Research Institute.
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Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking.
TL;DR: It is proposed that HIV "highjacks" TNT communication to spread HIV through an intercellular route between communicated cells, contributing to the pathogenesis of AIDS.
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Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.
TL;DR: This comprehensive review details the current information regarding concentrations of dopamine found in both the central nervous system and in many regions of the periphery, and discusses the immune cells present in each region, and how these could interact with dopamine in each compartment described.
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Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis.
Dionna W. Williams,Tina M. Calderon,Lillie Lopez,Loreto Carvallo-Torres,Peter J. Gaskill,Eliseo A. Eugenin,Susan Morgello,Joan W. Berman +7 more
TL;DR: Targeting CCR2, JAM-A, and ALCAM present on CD14+CD16+ monocytes that preferentially infiltrate the CNS represents a therapeutic strategy to reduce viral seeding of the brain as well as the ongoing neuroinflammation that occurs during HIV pathogenesis.
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Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders
Dionna W. Williams,Mike Veenstra,Peter J. Gaskill,Susan Morgello,Tina M. Calderon,Joan W. Berman +5 more
TL;DR: Mechanisms that mediate transmigration of CD14(+)CD16(+) monocytes across the BBB in the context of HIV infection, the contribution of these cells to the neuropathogenesis of HIV, and potential monocyte/macrophage biomarkers to identify HAND and monitor its progression are discussed.
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Human Immunodeficiency Virus (HIV) Infection of Human Macrophages Is Increased by Dopamine: A Bridge between HIV-Associated Neurologic Disorders and Drug Abuse
Peter J. Gaskill,Tina M. Calderon,Aimée J. Luers,Eliseo A. Eugenin,Jonathan A. Javitch,Joan W. Berman +5 more
TL;DR: A common mechanism by which drugs of abuse enhance HIV replication in macrophages is suggested and it is indicated that the drug abuse-heightened levels of central nervous system dopamine could increase viral replication, thereby accelerating the development of HAND.