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Susan Morgello
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 274
Citations - 18227
Susan Morgello is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neurocognitive & Viral load. The author has an hindex of 62, co-authored 259 publications receiving 16169 citations. Previous affiliations of Susan Morgello include Fordham University & Aristotle University of Thessaloniki.
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Journal ArticleDOI
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
Robert K. Heaton,David B. Clifford,Donald Franklin,Steven Paul Woods,Christopher Ake,Florin Vaida,Ronald J. Ellis,S. Letendre,Thomas D. Marcotte,Joseph H. Atkinson,Monica Rivera-Mindt,Ofilio Vigil,Michael J. Taylor,Ann C. Collier,Camillo Marra,Benjamin B. Gelman,Justin C. McArthur,Susan Morgello,David M. Simpson,McCutchan Ja,Ian Abramson,Anthony Gamst,Christine Fennema-Notestine,Terry L. Jernigan,Joseph K. Wong,Igor Grant +25 more
TL;DR: The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities.
Journal ArticleDOI
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
Robert K. Heaton,Donald Franklin,Ronald J. Ellis,J. Allen McCutchan,Scott Letendre,Shannon LeBlanc,Stephanie Corkran,Nichole A. Duarte,David B. Clifford,Steven Paul Woods,Ann C. Collier,Christina M. Marra,Susan Morgello,Monica Rivera Mindt,Michael J. Taylor,Thomas D. Marcotte,J. Hampton Atkinson,Tanya Wolfson,Benjamin B. Gelman,Justin C. McArthur,David M. Simpson,Ian Abramson,Anthony Gamst,Christine Fennema-Notestine,Terry L. Jernigan,Joseph K. Wong,Igor Grant +26 more
TL;DR: In this article, the authors used comparable methods of subject screening and assessments to classify neurocognitive impairment (NCI) in large groups of HIV + and HIV − participants from the pre-CART era (1988-1995, N = 857) and CART era(2000-2007; N = 937).
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Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
Scott Letendre,Jennifer Marquie-Beck,Edmund V. Capparelli,Brookie M. Best,David B. Clifford,Ann C. Collier,Benjamin B. Gelman,Justin C. McArthur,J. Allen McCutchan,Susan Morgello,David M. Simpson,Igor Grant,Ronald J. Ellis +12 more
TL;DR: Poorer penetration of ARV drugs into the CNS appears to allow continued HIV replication in the CNS as indicated by higher CSF HIV viral loads, which is probably critical in treating patients who have HIV-associated neurocognitive disorders.
Journal ArticleDOI
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.
Petronela Ancuta,Anupa Kamat,Kevin J. Kunstman,Eun Young Kim,Patrick Autissier,Alysse G. Wurcel,Tauheed Zaman,David Stone,Megan Mefford,Susan Morgello,Elyse J. Singer,Steven M. Wolinsky,Dana Gabuzda +12 more
TL;DR: A role for elevated LPS levels in driving monocyte activation in AIDS is suggested, thereby contributing to the pathogenesis of HAD, and evidence that cofactors linked to substance abuse and HCV co-infection influence these processes is provided.
Journal ArticleDOI
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain.
Melissa Cosenza-Nashat,Meng-Liang Zhao,Hyeon-Sook Suh,Janet Morgan,Ryan Natividad,Susan Morgello,Sunhee C. Lee +6 more
TL;DR: The first comprehensive immunohistochemical analysis of the expression of TSPO is provided, useful for informing the usage of positron emission tomography as an imaging modality and have an impact on the potential use of T SPO as an anti‐inflammatory pharmacological target.