P
Peter J Robinson
Researcher at Air Force Research Laboratory
Publications - 35
Citations - 459
Peter J Robinson is an academic researcher from Air Force Research Laboratory. The author has contributed to research in topics: Physiologically based pharmacokinetic modelling & Perchlorate. The author has an hindex of 9, co-authored 35 publications receiving 382 citations. Previous affiliations of Peter J Robinson include Henry M. Jackson Foundation for the Advancement of Military Medicine.
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Journal ArticleDOI
Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: a physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat.
Rebecca A. Clewell,Elaine A. Merrill,Kyung O. Yu,Deirdre A. Mahle,Teresa R Sterner,David R. Mattie,Peter J Robinson,Jeffrey W. Fisher,Jeffery M. Gearhart +8 more
TL;DR: A comparison of model-predicted internal dosimetrics in the adult male, pregnant, and fetal rat indicates that the fetal thyroid is more sensitive to inhibition than that of the adult.
Journal ArticleDOI
PBPK Model for Radioactive Iodide and Perchlorate Kinetics and Perchlorate-Induced Inhibition of Iodide Uptake in Humans
Elaine A. Merrill,Rebecca A. Clewell,Peter J Robinson,Annie M. Jarabek,Jeffery M. Gearhart,Teresa R Sterner,Jeffrey W. Fisher +6 more
TL;DR: The model's successful prediction of free and bound radioactive I- and perchlorate's interaction with free radioactive I - provide a basis for extending the structure to address the complex hypothalamic-pituitary-thyroid feedback system.
Journal ArticleDOI
PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat.
Elaine A. Merrill,Rebecca A. Clewell,Jeffery M. Gearhart,Peter J Robinson,Teresa R Sterner,Kyung O. Yu,David R. Mattie,Jeffrey W. Fisher +7 more
TL;DR: A physiologically-based pharmacokinetic model for the adult male rat that successfully predicts perchlorate's interaction with iodide provides a sound basis for future incorporation of the complex hypothalamic-pituitary-thyroid feedback system.
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Predicting Passive and Active Tissue:Plasma Partition Coefficients: Interindividual and Interspecies Variability
Christopher D. Ruark,Christopher D. Ruark,C. Eric Hack,Peter J Robinson,Deirdre A. Mahle,Jeffery M. Gearhart,Jeffery M. Gearhart +6 more
TL;DR: The results show K(t:pl) interspecies variability for the brain, fat, heart, kidney, liver, lung, muscle, red blood cell, skin, and spleen, but uncertainty in the estimates obscured some differences.
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Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip.
M. Tyler Nelson,Mark R. Charbonneau,Heidi G. Coia,Heidi G. Coia,Mary Castillo,Corey Holt,Eric S. Greenwood,Eric S. Greenwood,Peter J Robinson,Elaine A. Merrill,David Lubkowicz,Camilla A Mauzy +11 more
TL;DR: In this article, a human gut-chip model and a synthetic biotic designed for the treatment of phenylketonuria were applied to demonstrate dose-dependent production of a strain-specific biomarker, and to show reduced blood phenylalanine accumulation after administration of the engineered strain.