PBPK Model for Radioactive Iodide and Perchlorate Kinetics and Perchlorate-Induced Inhibition of Iodide Uptake in Humans
Elaine A. Merrill,Rebecca A. Clewell,Peter J Robinson,Annie M. Jarabek,Jeffery M. Gearhart,Teresa R Sterner,Jeffrey W. Fisher +6 more
TLDR
The model's successful prediction of free and bound radioactive I- and perchlorate's interaction with free radioactive I - provide a basis for extending the structure to address the complex hypothalamic-pituitary-thyroid feedback system.About:
This article is published in Toxicological Sciences.The article was published on 2004-10-13 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Perchlorate & Iodine.read more
Citations
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ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies
Paul M. Hinderliter,Kevin R. Minard,Kevin R. Minard,Galya Orr,Galya Orr,William B. Chrisler,Brian D. Thrall,Brian D. Thrall,Joel G. Pounds,Justin G. Teeguarden,Justin G. Teeguarden +10 more
TL;DR: The results confirm the hypothesis that for liquid-based in vitro systems, the dose-rates and target cell doses for all particles are not equal; they can vary significantly, in direct contrast to the assumption of dose-equivalency implicit in the use of mass-based media concentrations as metrics of exposure for dose-response assessment.
Journal ArticleDOI
Perchlorate exposure of the US Population, 2001-2002.
TL;DR: Assessment of perchlorate exposure in a nationally representative population of 2820 US residents, ages 6 years and older, during 2001 and 2002 as part of the National Health and Nutrition Examination Survey (NHANES), provides the first population-based assessment of the magnitude and prevalence of per chlorate exposure.
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Analysis of perchlorate in human urine using ion chromatography and electrospray tandem mass spectrometry.
TL;DR: A sensitive and selective method for quantifying perchlorate in human urine using ion chromatography coupled with electrospray ionization tandem mass spectrometry, resulting in a rugged and rapid method capable of routinely analyzing 75 samples/day.
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Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period.
R Téllez,Patricio Michaud Chacón,Carlos Reyes Abarca,Ben C. Blount,Cynthia Van Landingham,Kenny S. Crump,John P. Gibbs +6 more
TL;DR: Perchlorate in drinking water at 114 microg/L did not cause changes in neonatal thyroid function or fetal growth retardation, and analysis of maternal urinary perchlorate excretion indicates an additional dietary source of per chlorate.
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Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans.
TL;DR: The BPA human model, using two parameter sets reflecting two adult monkey studies, both predicted lower aglycone levels in human serum than the previous human BPA PBPK model predictions.
References
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Trace Elements in Human and Animal Nutrition
TL;DR: This book discusses the history of zinc, its application in agriculture, and its applications in the management of soil-Plant-Animal relations.
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Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
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Werner & Ingbar's the thyroid : a fundamental and clinical text
TL;DR: This edition of The Thyroid has added the surgical management of thyroid disorders which is clearly an asset for the endocrine surgeon and is clearly essential for endocrinologists and thyroid surgeons.
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The Pendred syndrome gene encodes a chloride-iodide transport protein.
TL;DR: It is demonstrated that pendrin functions as a transporter of chloride and iodide, but not sulfate, and may provide insight into thyroid physiology and the pathophysiology of Pendred syndrome.