P
Peter R. Cook
Researcher at University of Oxford
Publications - 214
Citations - 17605
Peter R. Cook is an academic researcher from University of Oxford. The author has contributed to research in topics: Transcription (biology) & DNA. The author has an hindex of 68, co-authored 209 publications receiving 16711 citations. Previous affiliations of Peter R. Cook include University of Edinburgh & Jagiellonian University.
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Journal ArticleDOI
The Organization of Replication and Transcription
TL;DR: An alternative model in which DNA and RNA polymerases are immobilized by attachment to larger structures, where they reel in their templates and extrude newly made nucleic acids is supported.
Journal ArticleDOI
Kinetics of Core Histones in Living Human Cells: Little Exchange of H3 and H4 and Some Rapid Exchange of H2b
Hiroshi Kimura,Peter R. Cook +1 more
TL;DR: The results reveal that the inner core of the nucleosome is very stable, whereas H2B on the surface of active nucleosomes exchanges continually, unlike H3-GFP and H4-G FP, which are commonly thought to represent transcriptionally active chromatin.
Journal ArticleDOI
Visualization of focal sites of transcription within human nuclei
TL;DR: Both nucleolar and extra‐nucleolar foci remain after nucleolytic removal of approximately 90% chromatin, suggesting an underlying structure probably organizes groups of transcription units into ‘factories’ where transcripts are both synthesized and processed.
Journal ArticleDOI
Active RNA polymerases are localized within discrete transcription "factories' in human nuclei.
TL;DR: Results are consistent with transcription occurring as templates slide past attached polymerases, as nascent RNA is extruded into the factories, which the authors call transcription 'factories'.
Journal ArticleDOI
Visualization of replication factories attached to a nucleoskeleton
TL;DR: HeLa cells in early S phase were encapsulated in agarose microbeads, permeabilized, and incubated with biotin-11-dUTP in a "physiological" buffer to provide visual evidence for polymerization "factories" fixed to a skeleton, with replication occurring as the template moves through them.