P
Peter R. Moore
Researcher at AstraZeneca
Publications - 16
Citations - 5083
Peter R. Moore is an academic researcher from AstraZeneca. The author has contributed to research in topics: Enantioselective synthesis & Nucleophile. The author has an hindex of 9, co-authored 14 publications receiving 4865 citations.
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Journal ArticleDOI
Fluorine in medicinal chemistry.
TL;DR: This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Journal ArticleDOI
Fluorine in Medicinal Chemistry
TL;DR: A tutorial review of fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency is provided in this paper. But the authors do not discuss the role of substitution.
Journal ArticleDOI
Asymmetric Electrophilic Fluorocyclization with Carbon Nucleophiles
Jamie R. Wolstenhulme,Jessica Rosenqvist,O. Lozano,John Ilupeju,Nathalie Wurz,Keary M. Engle,George W. Pidgeon,Peter R. Moore,Graham Sandford,Véronique Gouverneur +9 more
TL;DR: The development of a new class of chiral Selectfluor proved instrumental in developing an asymmetric variant of this transformation of prochiral alkenes into chiral N-F reagents, readily accessible by fluorine transfer from shelf-stable N-fluoropyridinium salts.
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Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ12-Prostaglandin J3
Andrejs Pelšs,Narasimhulu Gandhamsetty,James R. Smith,Damien Mailhol,Mattia Silvi,Andrew J.A. Watson,Isabel Perez-Powell,Sébastien Prévost,Nina Schützenmeister,Peter R. Moore,Varinder K. Aggarwal +10 more
TL;DR: The synthetic utility of this enal intermediate has been further demonstrated through the total synthesis of Δ12‐prostaglandin J3, a compound with known anti‐leukemic properties.
Journal ArticleDOI
Sequential Desymmetrization–Fluorination: Enantioselective Synthesis of Fluorinated Cyclitols
TL;DR: Full NMR spectroscopic analysis of the fluorinated monocyclic compounds revealed that a subtle combination of steric (1,3-axial/pseudoaxial interaction) and stereoelectronic effects (pi-sigma* interaction) favours the preferential conformers featuring the methoxy group in a pseudoaxial position.